Reduction of alveolar-capillary diffusion after inhalation of endotoxin in normal subjects.
Reduction of alveolar-capillary diffusion after inhalation of endotoxin in normal subjects.
复制标题
正常受试者吸入内毒素后肺泡毛细血管扩散减少。
作者：
A. Herbert;M. Carvalheiro;E. Rubenowitz;B. Bake;R. Rylander
正常受试者暴露于大肠杆菌内毒素气溶胶。此后在不同时间测定一氧化碳扩散（Dco）、肺量测定、血液中性粒细胞、白色血细胞和血小板。发现Dco显著降低，血液中性粒细胞增加，暴露后4至8小时效果最大。暴露于蒸馏水导致Dco降低的趋势和血液中性粒细胞的显着增加。未检测到对肺活量测定或体温的影响。这表明，观察到的变化代表了肺泡水平的炎症，出现在低于引起支气管收缩和发热的内毒素剂量水平。
Normal subjects were exposed to an aerosol of Escherichia coli endotoxin. Carbon monoxide diffusion (Dco), spirometry, blood neutrophils, white blood cells, and platelets were determined at various times thereafter. A significant decrease in Dco and an increase in blood neutrophils was found, with a maximum effect 4 to 8 h after exposure. Exposure to distilled water caused a tendency for Dco to decrease and a significant increase in blood neutrophils. No effect on spirometry or body temperature was detected. It is suggested that the changes observed represent an inflammation at the alveolar level that appears at dose levels of endotoxin below those which cause bronchoconstriction and fever.