ATHEROMA AND OTHER LESIONS PRODUCED IN RABBITS BY CHOLESTEROL FEEDING.
ATHEROMA AND OTHER LESIONS PRODUCED IN RABBITS BY CHOLESTEROL FEEDING.
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胆固醇喂养在兔子中产生的动脉瘤和其他病变。
DOI：
10.1084/jem.23.1.69
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发表时间：
1916-01-01
影响因子：
15.3
通讯作者：
Bailey, C H
中科院分区：
文献类型：
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作者：
Bailey, C H
给兔子喂蛋黄或纯胆固醇，会在各种器官中产生丰富的各向异性脂肪存款。这种存款的特征性损害继发于某些器官。这些病变中最突出的是主动脉粥样硬化，在大体和组织学上与人类病变非常相似。其他血管的病变也会产生，其中明显的是肺动脉分支的病变。肝内有大量的各向异性脂肪存款，可引起肝硬化。肾上腺的发生，可能是由于储存了过量的各向异性脂肪。在一定比例的家兔中，肾脏会产生明显的损伤，包括髓质部分各向异性脂肪的结节状沉积，脂肪大部分包含在间质组织中的内皮细胞和成纤维细胞中。随后，这些区域发生软化，如主动脉;细胞分解;有大量胆固醇晶体存款，一些钙化和结缔组织增生。疤痕经常从这些病变通过皮质向外延伸，但在皮质中从未看到各向异性脂肪的结节状沉积。从这些实验中不可能明确地确定这些沉积物是否依赖于预先存在的间质病变。
The feeding of egg yolk or pure cholesterol to rabbits produces an abundant deposit of anisotropic fat in various organs. From this deposit characteristic lesions secondarily result in certain organs. Prominent among these lesions is an atheroma of the aorta very similar in the gross and histologically to the human lesion. Lesions of other vessels are also produced, conspicuous among which are those of the branches of the pulmonary artery. There is a large deposit of anisotropic fat in the liver which produces a cirrhosis. Enlargement of the adrenals occurs, probably due to the storage of an excessive amount of anisotropic fat. In a certain proportion of rabbits conspicuous lesions are produced in the kidneys consisting of nodular deposits of anisotropic fat in the medullary portion, the fat being contained for the most part in endothelial cells and fibroblasts in the interstitial tissue. Later softening occurs in these areas as in the aorta; the cells break down; there is an abundant deposit of cholesterol crystals, some calcification, and a proliferation of connective tissue. Scars frequently extend outward from these lesions through the cortex, but the nodular deposits of anisotropic fat are never seen in the cortex. It is impossible to determine definitely from these experiments whether or not these deposits are dependent on preexisting interstitial lesions.