Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative.

Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative.
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DOI:
10.1097/01.aids.0000363779.65827.e0
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发表时间:
2009-11
期刊:
AIDS (London, England)
影响因子:
--
通讯作者:
MTCT-Plus Initiative
MTCT-Plus Initiative
中科院分区:
其他
文献类型:
--
作者:
Stringer EM;Giganti M;Carter RJ;El-Sadr W;Abrams EJ;Stringer JS;MTCT-Plus Initiative

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全世界1 540万感染人体免疫机能丧失病毒(艾滋病毒)的妇女中,大多数是育龄妇女,需要获得避孕药具。激素避孕方法是安全的,可接受的,并有效地防止意外怀孕。许多已发表的研究审查了激素避孕对艾滋病毒感染和传播的影响。很少有人研究激素避孕与艾滋病毒疾病进展之间的关系。本文综述了临床、动物和免疫学研究中关于这种关系的可用数据。一些临床研究表明了总体效果,但并不确定,HIV疾病进展背后的机制尚不清楚。动物和免疫学数据表明,激素避孕方法的免疫调节可能会影响对HIV感染的免疫反应。在这一领域还需要开展更多的工作,以阐明激素避孕方法与感染艾滋病毒的妇女发展为后天免疫机能丧失综合症之间可能存在的关系。
The majority of the 15.4 million human immunodeficiency virus (HIV)–infected women worldwide are of child-bearing age and need access to contraception. Hormonal methods of contraception are safe, acceptable, and effective in preventing unwanted pregnancies. Many published studies have examined the impact of hormonal contraception on HIV disease acquisition and transmissibility. Far fewer have investigated the relationship between hormonal contraception and HIV disease progression. This review examines available data on this relationship from clinical, animal, and immunological studies. Several clinical studies suggest an overall effect but are not definitive, and the mechanisms behind HIV disease progression are unclear. Animal and immunological data suggest that immunomodulation by hormonal contraceptive methods may affect the immune response to HIV infection. Additional work is needed in this area to elucidate the possible relationship between hormonal methods for birth control and progression to acquired immunodeficiency syndrome in HIV-infected women.
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