Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative.
Hormonal contraception and HIV disease progression: a multicountry cohort analysis of the MTCT-Plus Initiative.
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DOI:
10.1097/01.aids.0000363779.65827.e0
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发表时间:
2009-11
期刊:
影响因子:
--
通讯作者:
MTCT-Plus Initiative
中科院分区:
文献类型:
--
作者:
Stringer EM;Giganti M;Carter RJ;El-Sadr W;Abrams EJ;Stringer JS;MTCT-Plus Initiative
The majority of the 15.4 million human immunodeficiency virus (HIV)–infected women worldwide are of child-bearing age and need access to contraception. Hormonal methods of contraception are safe, acceptable, and effective in preventing unwanted pregnancies. Many published studies have examined the impact of hormonal contraception on HIV disease acquisition and transmissibility. Far fewer have investigated the relationship between hormonal contraception and HIV disease progression. This review examines available data on this relationship from clinical, animal, and immunological studies. Several clinical studies suggest an overall effect but are not definitive, and the mechanisms behind HIV disease progression are unclear. Animal and immunological data suggest that immunomodulation by hormonal contraceptive methods may affect the immune response to HIV infection. Additional work is needed in this area to elucidate the possible relationship between hormonal methods for birth control and progression to acquired immunodeficiency syndrome in HIV-infected women.
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