Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis
Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis
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DOI：
10.1016/j.bmc.2005.05.014
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发表时间：
2005-10-01
影响因子：
3.5
通讯作者：
Huthmacher, K
中科院分区：
文献类型：
--
作者：
Tsogoeva, SB;Hateley, MJ;Huthmacher, K
研究了新型和已知的吡啶基硫脲类化合物(HIV逆转录酶的非核苷抑制剂)在不对称Strecker合成中作为双功能有机催化剂的潜力。结果表明，咪唑基取代了吡啶基，合成了一种具有更高催化活性的新型硫脲衍生物。(C)2005爱思唯尔有限公司。保留所有权利。
The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the imidazolyl moiety in place of a pyridyl group results in a new thiourea derivative that displays a much higher catalytic activity. (c) 2005 Elsevier Ltd. All rights reserved.