Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta
Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta
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DOI：
10.1161/01.cir.0000031331.05368.9d
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发表时间：
2002-10-08
期刊：
影响因子：
37.8
通讯作者：
Yla-Herttuala, S
中科院分区：
文献类型：
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作者：
Laukkanen, MO;Kivelä, A;Yla-Herttuala, S
背景：动脉粥样硬化血管侵入性治疗后，再狭窄是一个常见的问题，并与内膜增生有关，内膜增生主要是由于平滑肌细胞的增殖和迁移，导致新内膜的形成。由于没有有效的常规药物治疗再狭窄，基因治疗是预防新内膜形成的一种潜在的新治疗方法。方法与结果：本研究分析了腺病毒介导的细胞外超氧化物歧化酶（EC-SOD）基因转染（3 × 10(9) pfu/kg）对球囊剥除兔主动脉新生内膜形成的影响。局部导管介导的基因转移到动脉壁减少再狭窄(P
Background-Restenosis is a frequent problem after invasive treatment of atherosclerotic vessels and is associated with intimal hyperplasia, which is primarily a result of proliferation and migration of smooth muscle cells, leading to the formation of neointima. Because there is no effective conventional medication for restenosis, gene therapy is a potential new treatment to prevent neointima formation.Methods and Results-In the present study, we analyzed the effects of adenovirus-mediated extracellular superoxide dismutase (EC-SOD) gene transfer (3x10(9) pfu/kg AdEC-SOD versus AdLacZ control virus) on neointima formation in balloon-denuded rabbit aortas. Local catheter-mediated gene transfer to the arterial wall reduced restenosis (P