Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy
复制标题
DOI：
10.1038/sj.npp.1301248
复制
发表时间：
2007-06-01
影响因子：
7.6
通讯作者：
Kumar, Anand
中科院分区：
文献类型：
--
作者：
Ajilore, Olusola;Haroon, Ebrahim;Kumar, Anand
2型糖尿病和重度抑郁症是共同的风险因素，可能具有相似的病理生理机制。为了进一步了解这些共同的机制，我们研究的目的是使用质子MRS检查2型糖尿病患者抑郁症的生化基础。2型糖尿病和重度抑郁症患者（n = 20）与糖尿病患者（n = 24）和健康对照组（n = 21）一起在1.5 T MRI/MRS扫描仪上进行沿着扫描。体素被放置在双侧背外侧白色物质和皮质下核区域，这两个区域在晚年抑郁症的回路中很重要。使用LC模型算法测量针对CSF校正的肌醇、肌酸、N-乙酰天冬氨酸、谷氨酸、谷氨酰胺和胆碱的绝对值。与健康人和糖尿病对照组相比，抑郁糖尿病患者皮层下区域的谷氨酰胺和谷氨酸浓度显著降低（p < 0.001）。与健康对照组相比，糖尿病对照组和抑郁糖尿病患者额叶白色物质中的肌醇浓度显著增加（p < 0.05）。这些研究结果具有广泛的意义，并建议改变谷氨酸和谷氨酰胺水平在皮层下区域沿着与白色物质的变化，肌醇提供重要的神经生物学底物的情绪障碍。
Type 2 diabetes and major depression are disorders that are mutual risk factors and may share similar pathophysiological mechanisms. To further understand these shared mechanisms, the purpose of our study was to examine the biochemical basis of depression in patients with type 2 diabetes using proton MRS. Patients with type 2 diabetes and major depression (n = 20) were scanned along with patients with diabetes alone (n = 24) and healthy controls (n = 21) on a 1.5 T MRI/MRS scanner. Voxels were placed bilaterally in dorsolateral white matter and the subcortical nuclei region, both areas important in the circuitry of late-life depression. Absolute values of myoinositol, creatine, N-acetyl aspartate, glutamate, glutamine, and choline corrected for CSF were measured using the LC-Model algorithm. Glutamine and glutamate concentrations in depressed diabetic patients were significantly lower (p < 0.001) in the subcortical regions as compared to healthy and diabetic control subjects. Myo-inositol concentrations were significantly increased (p < 0.05) in diabetic control subjects and depressed diabetic patients in frontal white matter as compared to healthy controls. These findings have broad implications and suggest that alterations in glutamate and glutamine levels in subcortical regions along with white matter changes in myo-inositol provide important neurobiological substrates of mood disorders.