Cancer risk among workers at Danish companies using trichloroethylene: A cohort study
Cancer risk among workers at Danish companies using trichloroethylene: A cohort study
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DOI：
10.1093/aje/kwg282
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发表时间：
2003-12-15
影响因子：
5
通讯作者：
Olsen, JH
中科院分区：
文献类型：
--
作者：
Raaschou-Nielsen, O;Hansen, J;Olsen, JH
三氯乙烯是一种动物致癌物，对人类致癌性的证据有限。对 347 家有使用三氯乙烯记录的丹麦公司的 40,049 名蓝领工人进行了队列评估，评估了 1968 年至 1997 年间的癌症发病率。男性总癌症的标准化发病率为 1.1（95% 置信区间 (CI)：1.04、1.12），女性为 1.2（95% CI：1.14、1.33）。对于非霍奇金淋巴瘤和肾细胞癌，总体标准化发病率分别为 1.2 (95% CI: 1.0, 1.5) 和 1.2 (95% CI: 0.9, 1.5)；标准化发病率随着工作时间的延长而增加，标准化发病率的升高仅限于 1980 年之前首次受雇的非霍奇金淋巴瘤工人和 1970 年之前首次受雇的肾细胞癌工人。食管腺癌的标准化发病率为 1.8（95% CI：1.2，2.7）；接触三氯乙烯概率最高的公司的标准化发病率较高。在由 14,360 名可能高度暴露的工人组成的亚队列中，非霍奇金淋巴瘤、肾细胞癌和食管腺癌的标准化发病率分别为 1.5 (95% CI: 1.2, 2.0)、1.4 (95% CI: 1.0, 1.8) 和 1.7 (95% CI: 0.9, 2.9)，分别。目前的结果和之前的研究结果表明，过去较高水平的三氯乙烯职业接触可能与非霍奇金淋巴瘤风险升高相关。三氯乙烯暴露与其他癌症之间的关联不太一致。
Trichloroethylene is an animal carcinogen with limited evidence of carcinogenicity in humans. Cancer incidence between 1968 and 1997 was evaluated in a cohort of 40,049 blue-collar workers in 347 Danish companies with documented trichloroethylene use. Standardized incidence ratios for total cancer were 1.1 (95% confidence interval (CI): 1.04, 1.12) in men and 1.2 (95% CI: 1.14, 1.33) in women. For non-Hodgkin's lymphoma and renal cell carcinoma, the overall standardized incidence ratios were 1.2 (95% CI: 1.0, 1.5) and 1.2 (95% CI: 0.9, 1.5), respectively; standardized incidence ratios increased with duration of employment, and elevated standardized incidence ratios were limited to workers first employed before 1980 for non-Hodgkin's lymphoma and before 1970 for renal cell carcinoma. The standardized incidence ratio for esophageal adenocarcinoma was 1.8 (95% CI: 1.2, 2.7); the standardized incidence ratio was higher in companies with the highest probability of trichloroethylene exposure. In a subcohort of 14,360 presumably highly exposed workers, the standardized incidence ratios for non-Hodgkin's lymphoma, renal cell carcinoma, and esophageal adenocarcinoma were 1.5 (95% CI: 1.2, 2.0), 1.4 (95% CI: 1.0, 1.8), and 1.7 (95% CI: 0.9, 2.9), respectively. The present results and those of previous studies suggest that occupational exposure to trichloroethylene at past higher levels may be associated with elevated risk for non-Hodgkin's lymphoma. Associations between trichloroethylene exposure and other cancers are less consistent.