Modelling fluorescence in clinical photodynamic therapy
Modelling fluorescence in clinical photodynamic therapy
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DOI：
10.1039/c2pp25271f
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发表时间：
2013-01-01
影响因子：
3.1
通讯作者：
Moseley, Harry
中科院分区：
文献类型：
--
作者：
Valentine, Ronan M.;Ibbotson, Sally H.;Moseley, Harry
近几十年来，了解非电离辐射与生物体的相互作用一直是许多研究的重点。这些相互作用的复杂性保证了理论和实验研究的发展，以深入了解预测和监测光动力治疗（PDT）方案的成功。有一个重大的推动力，以证据为基础的建议，病人的诊断，治疗和管理。PDT的生物物理方面的知识对于改进剂量测定方案是重要的。临床PDT中的荧光可用于检测和诊断癌前病变和恶性病变，而光漂白可监测治疗期间荧光的变化。结合经验的荧光光漂白临床数据与计算建模，使临床PDT剂量测定方案进行调查，以期优化治疗方案。我们将讨论如何蒙特卡罗辐射传输（MCRT）建模已插入荧光检测和PDT领域。在本文中，我们强调的重要方面的基础研究，光动力治疗的报告目前利用荧光在临床光动力治疗从临床和理论的角度。从这些角度理解和了解生物组织中的光传播应该对治疗计划产生积极影响。
Understanding the interactions of non-ionizing radiation with living organisms has been the focus of much research over recent decades. The complex nature of these interactions warrants development of theoretical and experimental studies to gain an insight into predicting and monitoring the success of photodynamic therapy (PDT) protocols. There is a major impetus towards evidence-based recommendations for patient diagnosis, treatment and management. Knowledge of the biophysical aspects of PDT is important for improving dosimetry protocols. Fluorescence in clinical PDT may be used to detect and diagnose pre-malignant and malignant conditions, while photobleaching can monitor changes in fluorescence during treatment. Combining empirical fluorescence photobleaching clinical data with computational modelling enables clinical PDT dosimetry protocols to be investigated with a view to optimising treatment regimes. We will discuss how Monte Carlo radiation transfer (MCRT) modelling has been intercalated in the field of fluorescence detection and PDT. In this paper we highlight important aspects of basic research in PDT by reporting on the current utilisation of fluorescence in clinical PDT from both a clinical and theoretical perspective. Understanding and knowledge of light propagation in biological tissue from these perspectives should have a positive impact on treatment planning.