EXSANGUINATION COOLING
EXSANGUINATION COOLING
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DOI：
10.1620/tjem.87.185
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发表时间：
1965-01-01
影响因子：
2.2
通讯作者：
IKEDA, S
中科院分区：
文献类型：
--
作者：
IKEDA, S
采用体外循环和大量稀释液对放血降温的血流动力学进行了研究。在5[degree]C下，通过狗肺体外灌注后葡聚糖溶液的氧含量高达3.4 vols %。采用放血降温法，可使食管与周围组织间的温度梯度降低，降温速度快。在冷却结束时，红细胞比容值降至5%。放血冷却组在复温期间的低总外周阻力表明血管阻塞比全血灌注犬少，后者显示出显著更高的值。10%低分子量葡聚糖的粘度与10 ℃时全血的粘度一样高。这种浓度的葡聚糖溶液不足以用于深度低温。在放血冷却中，整个手术过程所需的血液量显著少于全血预充组。用这种方法，在食管温度低于10 ℃时，30分钟的完全停循环实验中获得了75%的高存活率。进一步延长停搏时间，存活率下降。
The hemodynamics of exsanguination cooling were studied with the use of extracorporeal circulation and a large amount of diluent. The oxygen content of dextran solution after in vitro perfusion through the dog''s lung was as much as 3.4 vols % at 5[degree]C. By using the method of exsanguination cooling, a high cooling rate and low gradient of temperature between esophagus and peripheral tissues were obtained. At the end of cooling the hematocrit value fell to 5%. Low total peripheral resistance in the exsanguination cooling group during rewarming suggests less vaso-obstruction than in whole blood perfused dogs who showed a significantly higher value. Viscosity of 10% low molecular weight dextran was as high as that of the whole blood at 10[degree]C. This concentration of dextran solution is inadequate for use in profound hypothermia. The amount of blood necessary for the entire course of an operation in exsanguination cooling was remarkably less than that in that whole blood priming group. With this method a high survival rate of 75% was obtained in experiments with total circulatory arrest of 30 minutes duration at below 10[degree]C esophageal temperature. Further extension of arrest time decreased the survival rate.