Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth
Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth
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DOI：
10.1016/0166-4328(96)00067-8
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发表时间：
1995-12
影响因子：
2.7
通讯作者：
M. Detke;I. Lucki
中科院分区：
文献类型：
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作者：
M. Detke;I. Lucki
描述了一种新的评分技术，用于测量大鼠在强迫游泳试验中的主动行为，该试验预测抗抑郁药物的作用。该技术区分了选择性5-羟色胺再摄取抑制剂的作用，其减少不动性并增加游泳行为，选择性去甲肾上腺素再摄取抑制剂，其减少不动性并增加攀爬行为。每种药物所描述的行为效应的大小（即，两种药物的不动性降低，氟西汀的游泳增加，地昔帕明的攀爬增加）在较深的30-cm而不是浅的15-cm水深进行测试时更大。该技术获得的结果表明，选择性5-羟色胺再摄取抑制剂在大鼠强迫游泳试验中不是假阴性，如以前所认为的。
A new scoring technique is described that measures active behaviors of rats in the forced swimming test, a test that predicts antidepressant drug effects. The technique distinguishes the effects of selective serotonin reuptake inhibitors, which reduce immobility and increase swimming behavior, from selective norepinephrine reuptake inhibitors, which reduce immobility and increase climbing behavior. The magnitude of behavioral effects described for each drug (i.e., reduced immobility for both drugs, increased swimming for fluoxetine, increased climbing for desipramine) was greater when testing was conducted at the deeper 30-cm rather than the shallow 15-cm water depth. Results obtained with the technique demonstrate that selective serotonin reuptake inhibitors are not false negatives in the rat forced swimming test, as previously thought.