Ecological study of solar radiation and cancer mortality in Japan
Ecological study of solar radiation and cancer mortality in Japan
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DOI：
10.1097/01.hp.0000137179.03423.0b
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发表时间：
2004-11-01
期刊：
影响因子：
2.2
通讯作者：
Mizoue, T
中科院分区：
文献类型：
--
作者：
Mizoue, T
对高纬度地区一些癌症死亡率上升的地理观察导致了一种假设，即暴露在太阳辐射下后产生的维生素D具有抗癌作用。然而，目前还不清楚这种联系是否会出现在日本这样的国家，在这些国家，鱼类的消费量很高，因此饮食中的维生素D摄入量也很高。计算了日本47个县1961年至1990年的年均太阳辐射水平与2000年癌症死亡率之间的皮尔逊相关系数，并对地区人均收入和饮食因素进行了调整。无论男女，食道癌、胃癌、结肠癌、直肠癌、胰腺癌、胆囊癌和胆管癌与太阳辐射呈中度负相关(相关系数在-0.6到-0.3之间)。这项研究的结果支持了这样的假设，即增加暴露在太阳辐射下可以降低患消化器官癌症的风险。
Geographic observation of the increased mortality of some cancers at higher latitudes has led to a hypothesis that vitamin D produced after exposure to solar radiation has anti-carcinogenic effects. However, it is unclear whether such association would be observed in countries like Japan, where fish consumption, and therefore dietary vitamin D intake, is high. Pearson correlation coefficients were calculated between averaged annual solar radiation levels for the period from 1961 through 1990 and cancer mortality in the year 2000 in 47 prefectures in Japan, with adjustments for regional per capita income and dietary factors. A moderate, inverse correlation with solar radiation was observed for cancers of the esophagus, stomach, colon, rectum, pancreas, and gallbladder and bile ducts in both sexes (correlation coefficient, ranging from -0.6 to -0.3). The results of this study support the hypothesis that increased exposure to solar radiation reduces the risk of cancers of the digestive organs.