Drinking water treatment is not associated with an observed increase in neural tube defects in mice.
Drinking water treatment is not associated with an observed increase in neural tube defects in mice.
复制标题
饮用水处理与观察到的小鼠神经管缺陷增加无关。
DOI：
10.1007/s10661-014-3652-6
复制
发表时间：
2014
影响因子：
3
通讯作者：
Hrubec,TerryC
中科院分区：
文献类型：
--
作者：
Melin,VanessaE;Johnstone,DavidW;Etzkorn,FeliciaA;Hrubec,TerryC
当源水中的天然有机物与水处理过程中使用的消毒剂发生反应时，就会产生消毒副产物（DBPs）。研究表明，舒张压与出生缺陷之间存在关联。2006年5月首次在内部观察到未经治疗的对照小鼠胚胎中的神经管缺陷（NTDs），并一直持续到今天。以前确定的ntd诱发剂的来源是饮用水的一种成分。分析了来自不同来源的自来水样本中的三卤甲烷（THMs），以确定它们是否导致了畸形。给CD-1小鼠提供处理过和未处理过的地表水，观察NTDs。被忽视热带病的发生因水源和处理方案而异。在来自地表水的自来水中检测到THMs，但在来自地下水的自来水中未检测到THMs。未经处理的河水和实验室纯净水中不存在THMs，但未经处理的河水中ntd的百分比与处理过的水相似。这些结果表明，THMs并不是引起ntd的主要原因，因为ntd的发生与饮用水消毒无关。
Disinfection by-products (DBPs) arise when natural organic matter in source water reacts with disinfectants used in the water treatment process. Studies have suggested an association between DBPs and birth defects. Neural tube defects (NTDs) in embryos of untreated control mice were first observed in-house in May 2006 and have continued to date. The source of the NTD-inducing agent was previously determined to be a component of drinking water. Tap water samples from a variety of sources were analyzed for trihalomethanes (THMs) to determine if they were causing the malformations. NTDs were observed in CD-1 mice provided with treated and untreated surface water. Occurrence of NTDs varied by water source and treatment regimens. THMs were detected in tap water derived from surface water but not detected in tap water derived from a groundwater source. THMs were absent in untreated river water and laboratory purified waters, yet the percentage of NTDs in untreated river water were similar to the treated water counterpart. These findings indicate that THMs were not the primary cause of NTDs in the mice since the occurrence of NTDs was unrelated to drinking water disinfection.