SELECTIVE ADJUSTMENT OF THE SPEED OF INTERNAL CLOCK AND MEMORY PROCESSES
SELECTIVE ADJUSTMENT OF THE SPEED OF INTERNAL CLOCK AND MEMORY PROCESSES
复制标题
DOI：
10.1037/0097-7403.9.2.171
复制
发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
MECK, WH
中科院分区：
文献类型：
--
作者：
MECK, WH
四个实验研究了雄性Charles River白化病大鼠的时间缩放，以确定是否可以通过药理学操作选择性地调整内部时钟和记忆过程。实验使用的时间歧视程序，其中1响应（“短”）被加强后2秒的噪声信号和不同的响应（“长”）被加强后8秒的噪声信号;中间持续时间的未加强信号也提出。长反应的比例随着信号持续时间的增加而增加。所有药物均为IP给药。在实验I中，甲基苯丙胺选择性地增加时钟速度，氟哌啶醇选择性地降低时钟速度。在实验II中，足电击应力增加时钟速度在连续管理，但降低时钟速度低于控制值时，突然终止足电击。实验三表明，加压素和催产素选择性地减少记忆的持续时间的加强时间，这表明，记忆存储速度增加。在实验四，毒扁豆碱减少，阿托品增加，这些记住的持续时间，这表明记忆存储速度的差异影响。它的结论是，内部时钟和内存过程可以分离，通过选择性地调整其操作速度，这些变化可以定量建模的标量定时理论。(61参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Four experiments studied the scaling of time by male Charles River albino rats to determine if internal clock and memory processes could be selectively adjusted by pharmacological manipulations. Experiments used a temporal discrimination procedure in which 1 response (" short") was reinforced following a 2-sec noise signal and a different response (" long") was reinforced following an 8-sec noise signal; unreinforced signals of intermediate duration were also presented. The proportion of long responses increased as a function of signal duration. All drugs were administered ip. In Exp I, methamphetamine selectively increased and haloperidol selectively decreased clock speed. In Exp II, footshock stress increased clock speed during continuous administration but decreased clock speed below control values when the footshock was abruptly terminated. Exp III demonstrated that vasopressin and oxytocin selectively decreased the remembered durations of reinforced times, which suggests that memory storage speed increased. In Exp IV, physostigmine decreased, and atropine increased, these remembered durations, which suggests that memory storage speed was differentially affected. It is concluded that internal clock and memory processes can be dissociated by selectively adjusting their speed of operation and that these changes can be quantitatively modeled by a scalar timing theory.(61 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)