Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice.
Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice.
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芍药苷和白花苷对放疗所致骨髓抑制小鼠的造血作用
DOI：
10.1155/2016/5789381
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Zhu Y;Wang L;Yang Z;Wang J;Li W;Zhou J;Zhang J
芍药根（白芍）是一种常用的中药。芍药苷（Paeoniflorin， PF）和芍药苷（albiflorin， AF）是芍药中的两种主要活性成分。本研究旨在探讨PF和AF对放疗所致骨髓抑制小鼠的造血作用，并探讨其机制。结果表明，PF和AF均能显著增加胸腺白细胞（WBC）数量，逆转胸腺萎缩。此外，PF和AF提高了粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-3 （IL-3）水平，降低了血清中肿瘤坏死因子-α (TNF-α)水平，升高了血浆中集落刺激因子（G-CSF）水平。最后，PF和AF不仅提高了脾脏中GM-CSF和G-CSF的mRNA水平，还提高了骨髓中G-CSF和GM-CSF的蛋白水平。我们的研究结果表明，PF和AF可能促进骨髓抑制小鼠模型骨髓造血功能的恢复。
Paeonia lactiflora root (baishao in Chinese) is a commonly used herb in traditional Chinese medicine (TCM). Paeoniflorin (PF) and albiflorin (AF) are two major active constituents of P. lactiflora. In this paper, we aimed to investigate the hematopoietic effects of PF and AF on myelosuppression mice induced by radiotherapy and to explore the underlying mechanism. The finding indicated that PF and AF significantly increased the numbers of white blood cells (WBC) and reversed the atrophy of thymus. Furthermore, PF and AF increased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) and reduced the levels of tumor necrosis factor-α (TNF-α) in serum and increased the level of colony-stimulating factor (G-CSF) in plasma. Lastly, PF and AF not only enhanced the mRNA levels of GM-CSF and G-CSF in the spleens, but also increased the protein levels of G-CSF and GM-CSF in bone marrow. Our results suggest that PF and AF may promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model.