The related murine kinases, Nek6 and Nek7, display distinct patterns of expression
The related murine kinases, Nek6 and Nek7, display distinct patterns of expression
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DOI：
10.1016/s0925-4773(01)00573-1
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发表时间：
2002-01-01
影响因子：
2.6
通讯作者：
Motro, B
中科院分区：
文献类型：
--
作者：
Feige, E;Motro, B
Nek6和Nek7是在结构上与曲霉属有丝分裂调节因子NIMA相关的进化上保守的鼠激酶（Genomics 68（2000）187）。比较原位检测他们的表达模式显示，在早期胚胎发育nek6是高度表达在初级巨大滋养层细胞，而nek7表达在蜕膜反应的网站。在胚胎发育后期，这两种RNA几乎完全局限于神经系统。发现nek 6存在于脑室和脑室下区域，而nek 7在背侧丘脑中高度表达。在成人大脑中，不同的细胞核表达这两种基因。谱系和组织特异性表达模式表明，这两种NIMA相关激酶具有与NIMA有丝分裂功能无关的（额外）功能。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Nek6 and Nek7 are evolutionarily conserved murine kinases structurally related to the Aspergillus mitotic-regulator NIMA (Genomics 68 (2000) 187). Comparative in situ examination of their patterns of expression revealed that during early embryogenesis nek6 is highly expressed in primary giant trophoblast cells, while nek7 is expressed in the site of decidual reaction. Later in embryogenesis, both RNAs are almost exclusively restricted to the nervous system. nek6 is found in ventricular and sub-ventricular regions, while nek7 is highly expressed in the dorsal thalamus. In the adult brain, distinct nuclei express the two genes. The lineage- and tissue-specific patterns of expression suggest that the two NIMA-related kinases have (additional) functions that are not related to the mitotic functions of NIMA. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.