Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment
Hippocampal volume is associated with memory but not nonmemory cognitive performance in patients with mild cognitive impairment
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DOI：
10.1385/jmn:20:3:241
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发表时间：
2003-01-01
影响因子：
3.1
通讯作者：
Thal, LJ
中科院分区：
文献类型：
--
作者：
Grundman, M;Lack, CR;Thal, LJ
轻度认知障碍（MCI）似乎是阿尔茨海默病（AD）发展的过渡阶段。与正常老年对照相比，MCI 患者表现出记忆力受损和海马萎缩。先前的研究表明，MCI 患者海马萎缩的程度预示着 AD 的转变。与主要存在记忆缺陷的 MCI 患者相比，AD 患者在记忆和非记忆认知领域都存在临床上明显的损害。对于海马体积较小预示着 AD 转化的观察结果，一种解释可能是海马萎缩与非记忆认知区域和记忆的早期损伤有关。如果海马萎缩与其他大脑区域的 AD 病理相关，则海马体积和非记忆功能之间可能存在联系。因此，我们试图确定 MCI 患者海马体积与记忆和非记忆任务表现的关系。尽管我们发现海马体积和记忆表现之间存在显着相关性，但我们没有发现海马体积和非记忆表现之间存在显着相关性。我们得出的结论是，海马体积与 AD 风险之间的关系可能与记忆能力下降有关，而与非记忆认知领域的损害无关。
Mild cognitive impairment (MCI) appears to be a transitional stage in the development of Alzheimer's disease (AD). Patients with MCI show impaired memory performance and hippocampal atrophy relative to normal elderly controls. Prior studies indicate that the degree of hippocampal atrophy in MCI patients predicts conversion to AD. In contrast to patients with MCI who have deficits primarily in memory, AD patients have clinically evident impairments in both memory and nonmemory cognitive domains. One explanation for the observation that a smaller hippocampal volume predicts conversion to AD might be that hippocampal atrophy is associated with early impairment in nonmemory cognitive areas as well as memory. A link between hippocampal volume and nonmemory function could occur if hippocampal atrophy was correlated with AD pathology in other brain regions. We therefore sought to determine the relationship of hippocampal volume with performance on memory and nonmemory tasks in patients with MCI. Although we found a significant correlation between hippocampal volume and memory performance, we did not find a significant correlation between hippocampal volume and nonmemory performance. We conclude that the relationship between hippocampal volume and risk of AD is likely tied to reduced memory performance and not associated with impairment in nonmemory cognitive domains.