NALOXONE AND PLAY FIGHTING IN JUVENILE RATS
NALOXONE AND PLAY FIGHTING IN JUVENILE RATS
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DOI：
10.1016/0091-3057(82)90470-1
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
COSTELLO, KB
中科院分区：
文献类型：
--
作者：
BEATTY, WW;COSTELLO, KB
根据阿片样物质社会依恋假说，阿片受体阻滞剂应该增加社会接触的需要。然而，纳洛酮减少了玩耍打斗，这是年轻大鼠社会互动的一种主要形式。如果纳洛酮在其他社会活动中产生补偿性增加，或者如果纳洛酮缩短了玩耍打斗的时间而不降低其频率，则该观察结果可能与阿片类物质依恋假说相一致。纳洛酮以剂量依赖性方式减少玩耍打斗。玩耍次数减少，持续时间不变，观察到社交嗅闻和梳理没有补偿性增加。纳洛酮抑制直立的可能性几乎与影响玩耍打斗的可能性相同。
According to the opioid hypothesis of social attachment, opiate receptor blockade should increase the need for social contact. Yet naloxone reduces play-fighting, a major form of social interaction in young rats. This observation might be reconciled with the opioid attachment hypothesis if naloxone produced compensatory increases in other social activities or if naloxone shortened play-fighting bouts without reducing their frequency. Naloxone reduced play-fighting in a dose-dependent fashion. The frequency of play bouts was reduced, their duration unchanged and no compensatory increase in social sniffing and grooming was observed. Naloxone inhibited rearing almost as potentialy as if affected play-fighting.