ETHANOL SPECIFICALLY POTENTIATES GABA-MEDIATED NEUROTRANSMISSION IN FELINE CEREBRAL-CORTEX
ETHANOL SPECIFICALLY POTENTIATES GABA-MEDIATED NEUROTRANSMISSION IN FELINE CEREBRAL-CORTEX
复制标题
DOI：
10.1126/science.7394531
复制
发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
NESTOROS, JN
中科院分区：
文献类型：
--
作者：
NESTOROS, JN
乙醇可增强γ-氨基丁酸对皮层神经元的抑制作用。这种效应是特异性的，因为乙醇不会增强甘氨酸、血清素或多巴胺的抑制作用。这些结果对酒精中毒有意义，因为（i）γ-氨基丁酸介导抗焦虑机制，（ii）焦虑与酒精中毒的病因有关。
Ethanol (ethyl alcohol) potentiates the inhibition of cortical neurons by γ-aminobutyric acid. This effect is specific, since ethanol does not potentiate inhibition by glycine, serotonin, or dopamine. These results have implications for alcoholism because (i) γ-aminobutyric acid mediates anxiolytic mechanisms, and (ii) anxiety is implicated in the etiology of alcoholism.