Cp*CoIII-Catalyzed Dehydrative C-H Allylation of 6-Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols
Cp*CoIII-Catalyzed Dehydrative C-H Allylation of 6-Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols
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DOI：
10.1021/acs.orglett.6b00846
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发表时间：
2016-05-06
期刊：
影响因子：
5.2
通讯作者：
Matsunaga, Shigeki
中科院分区：
文献类型：
--
作者：
Bunno, Youka;Murakami, Nanami;Matsunaga, Shigeki
以烯丙醇为烯丙基化试剂，Cp ~*Co-III催化各种芳香C-H键的C-H烯丙基化反应。使用氟化醇溶剂的改进的反应条件提供了6-芳基嘌呤、苯甲酰胺和具有良好官能团相容性的合成有用的Weinreb酰胺的有效的定向C-H烯丙基化。
Cp*Co-III-catalyzed C-H allylation of various aromatic C-H bonds using allyl alcohols as allylating reagents is described. Improved reaction conditions using fluorinated alcohol solvents afforded efficient directed C-H allylation of 6-arylpurines, benzamides, and a synthetically useful Weinreb amide with good functional group compatibility.