Family study of girls with attention deficit hyperactivity disorder
Family study of girls with attention deficit hyperactivity disorder
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DOI：
10.1176/appi.ajp.157.7.1077
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发表时间：
2000-07-01
影响因子：
17.7
通讯作者：
Zallen, B
中科院分区：
文献类型：
--
作者：
Faraone, SV;Biederman, J;Zallen, B
目的：由于注意缺陷多动障碍（ADHD）在女孩中相对少见，因此对女孩ADHD的病因了解甚少。为了帮助填补这一文献空白，作者评估了通过女孩确定的家庭中ADHD的家族遗传。方法：对140名ADHD女孩及其417名一级亲属和122名非ADHD女孩及其369名一级亲属进行了结构化精神病学访谈。结果：根据DSM-III-R或DSM-IV的定义，ADHD女孩的亲属比对照女孩的亲属有明显更高的ADHD患病率。然而，这与作者之前报道的患有多动症男孩家庭的患病率并没有什么不同。与男孩的家庭一样，女孩先证者的亲属也有明显更高的反社会、情绪、焦虑和物质使用障碍的患病率，尽管家庭反社会障碍的患病率低于男孩的家庭。先证者的DSM-IV亚型与亲属之间无相关性。结论：ADHD和合并症的家族遗传普遍存在于ADHD女孩的家庭中。先证者性别和亚型都不影响ADHD的家族遗传。
Objective: Because attention deficit hyperactivity disorder (ADHD) is relatively infrequent among girls, little is known about the causes of ADHD in girls. To help fill this gap in the literature, the authors assessed the familial transmission of ADHD in families ascertained through girls.Method: Interviewers who were blind to diagnosis administered structured psychiatric interviews to 140 girls with ADHD and their 417 first-degree relatives and to 122 girls without ADHD and their 369 first-degree relatives.Results: The relatives of the ADHD girls had a significantly higher prevalence of ADHD, according to either the DSM-III-R or DSM-IV definition, than the relatives of the comparison girls. However, this did not differ from the prevalence the authors reported previously for families of boys with ADHD. Like the boys' families, the relatives of the girl probands also had significantly higher prevalences of antisocial, mood, anxiety, and substance use disorders, although the prevalence of familial antisocial disorders was lower than had been observed in the boys' families. There was no association between the DSM-IV subtypes of the probands and relatives.Conclusions: The familial transmission of ADHD and comorbid disorders generalizes to families of girls with ADHD. Neither proband gender nor subtype influences the familial transmission of ADHD.