Outdoor activity and myopia progression in 4-year follow-up of Chinese primary school children: The Beijing Children Eye Study.
Outdoor activity and myopia progression in 4-year follow-up of Chinese primary school children: The Beijing Children Eye Study.
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中国小学生四年随访户外活动与近视进展：北京儿童眼科研究
DOI：
10.1371/journal.pone.0175921
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Jonas JB
中科院分区：
文献类型：
--
作者：
Guo Y;Liu LJ;Tang P;Lv YY;Feng Y;Xu L;Jonas JB
在北京小学生中进行一项为期4年的随访，以调查与眼轴延长和近视进展相关的因素。
这项基于学校的研究在2011年基线时纳入了382名一年级儿童（年龄：6.3±0.4岁），其中305名（79.8%）在2015年返回参加随访检查。在基线以及每年的随访检查中，儿童接受了全面的眼部检查，包括自动验光、测量眼轴长度的眼部生物测量以及眼底照相。家长接受了标准化访谈。
在研究期间，男孩的平均眼轴长度延长了1.15±0.56毫米，女孩延长了1.10±0.63毫米。在基线和随访结束时，男孩的眼轴长度明显更长（P<0.001），而眼轴延长在性别之间没有差异（P = 0.50）。在多变量分析中，眼轴延长更多与户外活动时间更少（P = 0.004；标准化系数β：-0.22）、室内学习时间更多（P = 0.02；β：0.18）以及父亲近视（P = 0.03；β：0.16）相关（回归系数r²：0.15）。眼轴长度/角膜前表面曲率（AL/CC）比值的更大增加与户外活动时间更少（P = 0.003；β：-0.22）以及母亲近视（P = 0.02；β：0.18）相关（r²：0.09）。
在4年随访期间的近视性眼轴延长与户外活动时间较短、室内学习时间较长以及父母近视有关。其他因素，如父亲教育水平、家庭收入、性别和居住地区，仅在单变量分析中与眼轴延长和近视进展显著相关。
To investigate factors associated with ocular axial elongation and myopia progression during a 4-year follow-up in primary school children in Beijing. This school-based study included 382 grade-1 children at baseline in 2011 (age:6.3±0.4 years) with 305 (79.8%) returning for the follow-up examination in 2015. At baseline and in yearly follow-up examinations, the children underwent a comprehensive eye examination including auto-refractometry, ocular biometry with measurement of axial length, and fundus photography. The parents underwent a standardized interview. During the study period, the mean axial length elongated by 1.15±0.56mm in boys and 1.10±0.63mm in girls. At baseline and at the end of follow-up, axial length was significantly (P<0.001) longer in boys, with no difference (P = 0.50) between genders in axial elongation. In multivariate analysis, greater axial elongation was associated (regression coefficient r2:0.15) with less time spent outdoors (P = 0.004; standardized coefficient beta: -0.22), more time spent indoors with studying (P = 0.02; beta: 0.18) and paternal myopia (P = 0.03; beta: 0.16). Larger increases in the axial length/anterior corneal curvature (AL/CC) ratio were associated (r2:0.09) with less time spent outdoors (PP = 0.003; beta: -0.22) and maternal myopia (PP = 0.02; beta: 0.18). Myopic axial elongation during a 4-year follow-up was associated with shorter time spent outdoors and longer time spent indoors studying and with parental myopia. Other factors such as level of paternal education, family income, gender and region of habitation were significantly associated with axial elongation and with myopia progression only in univariate analysis.