An Optimized Version of the Positive and Negative Symptoms Scale (PANSS) for Pediatric Trials.
An Optimized Version of the Positive and Negative Symptoms Scale (PANSS) for Pediatric Trials.
复制标题
用于儿科试验的阳性和阴性症状量表 (PANSS) 的优化版本。
DOI：
10.1016/j.jaac.2022.07.864
复制
发表时间：
2023
影响因子：
13.3
通讯作者：
Busner,Joan
中科院分区：
文献类型：
--
作者：
Findling,RobertL;Youngstrom,EricA;McClellan,JonM;Frazier,JeanA;Sikich,Linmarie;Daniel,DavidGordon;Busner,Joan
ObjectiveThe accepted primary outcome measure for evaluating psychotic symptoms is decades old, long, and initially designed for adults. Surprisingly, the psychometric properties of primary outcome measures have never been reported for a pediatric sample using modern methods. The present study’s aim is to use a pediatric sample to evaluate the psychometrics of the most used primary outcome measure in pediatric schizophrenia trials, the Positive and Negative Syndrome Scale (PANSS).MethodTo evaluate the factor structure, item characteristics, and treatment sensitivity of the PANSS in a pediatric sample, secondary analyses of PANSS data at baseline and weekly throughout an 8-week randomized double-blind study of 3 antipsychotic agents (registered and previously published) were conducted. Subjects were 118 youths receiving outpatient psychiatric treatment for schizophrenia spectrum disorders (mean age = 14.26 years, SD = 2.41 years).ResultsA 10-item short form, keeping 2 strongest items for each factor, hadr= 0.89 with the full-length scale. Each of the five 2-item subscales has alphas ranging from 0.66 to 0.84. Item Response Theory (IRT) found that the 10-item scale and 2-item subscores had high reliability across the severity range typical of those for clinical trials. Criterion validity was high, with equal sensitivity to clinical changes over time.ConclusionA 10-item PANSS version eliminates weaker items in the pediatric population while preserving coverage of 5 factors and similar sensitivity to clinical changes over time. It thus may be more appropriate for subsequent pediatric trials, and for clinical use when time and efficiency are paramount.
