REACTIVATION OF HEPATITIS-B AFTER TRANSPLANTATION OPERATIONS
REACTIVATION OF HEPATITIS-B AFTER TRANSPLANTATION OPERATIONS
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DOI：
10.1016/s0140-6736(77)91995-x
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发表时间：
1977-01-01
期刊：
影响因子：
168.9
通讯作者：
COHEN, BJ
中科院分区：
文献类型：
--
作者：
NAGINGTON, J;COSSART, YE;COHEN, BJ
自1968年以来，对剑桥移植和透析中心[剑桥，英国]的工作人员和病人进行乙肝感染监测，发现8年内有6例病人发生抗原血症。对每位入院患者的第一次血清进行抗-HBc [乙型肝炎B核心抗原]抗体检查，380例患者中有23例（6.1%）阳性。由于抗-BHc的存在被认为是既往感染的证据，在移植后免疫抑制的3例阳性患者中发生抗原血症可能是由于潜伏感染的重新激活。这是移植后控制B型肝炎需要考虑的一个新因素。
Surveillance of the staff and patients at the Cambridge transplant and Dialysis Unit [Cambridge, England] for hepatitis-B infection since 1968 revealed the onset of antigenemia in 6 patients in 8 yr. The 1st serum of each patient admitted was examined for anti-HBc [hepatitis B core antigen] antibody, and 23 of 380 (6.1%) patients were positive. Since the presence of anti-BHc is taken to be evidence of previous infection, the occurrence of antigenemia in 3 of the positives when they were immunosuppressed after transplantation is probably due to reactivation of latent infection. This is a new factor to be considered in the control of hepatitis B after transplantation.