BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses
BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses
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DOI：
10.1038/sj.emboj.7601742
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发表时间：
2007-07-11
期刊：
影响因子：
11.4
通讯作者：
Wirth, Thomas
中科院分区：
文献类型：
--
作者：
Brunner, Cornelia;Sindrilaru, Anca;Wirth, Thomas
BOB.1 /票据。1是在b细胞发育的几个阶段必不可少的转录辅激活因子。在T细胞中，BOB.1/OBF。共刺激诱导表达。然而，BOB.1/OBF的定义角色。到目前为止，还没有发现t细胞功能的1。这里，我们展示了BOB.1/OBF。1对辅助性T细胞功能至关重要。BOB.1 /票据。1（-/-）小鼠表现出不平衡的免疫反应，导致对利什曼原虫主要感染的易感性增加。功能分析揭示了TH1和TH2细胞的特异性缺陷。TH1细胞因子的表达水平降低，TH2细胞因子的分泌增加。BOB.1 /票据。1直接参与IFN γ和IL2启动子活性。相比之下，TH2细胞因子的增加是间接控制的，可能是通过转录因子PU.1，其表达受BOB.1/OBF.1调节。因此,BOB.1 /票据。1调节TH1与TH2介导免疫的平衡。
BOB.1/OBF.1 is a transcriptional coactivator essential at several stages of B-cell development. In T cells, BOB.1/OBF.1 expression is inducible by co-stimulation. However, a defined role of BOB.1/OBF.1 for T-cell function had not been discovered so far. Here, we show that BOB.1/OBF.1 is critical for T helper cell function. BOB.1/OBF.1(-/-) mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection. Functional analyses revealed specific defects in TH1 and TH2 cells. Whereas expression levels of TH1 cytokines were reduced, the secretion of TH2 cytokines was increased. BOB.1/OBF.1 directly contributes to the IFN gamma and IL2 promoter activities. In contrast, increased TH2 cytokine production is controlled indirectly, probably via the transcription factor PU.1, the expression of which is regulated by BOB.1/OBF.1. Thus, BOB.1/OBF.1 regulates the balance of TH1 versus TH2 mediated immunity.