Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods
Bridging one helical turn in double-stranded DNA by templated dimerization of molecular rods
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DOI：
10.1002/anie.200800819
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Gothelf, Kurt V.
中科院分区：
文献类型：
--
作者：
Andersen, Casper S.;Yan, Hao;Gothelf, Kurt V.
分子桥：由取代的低聚（亚苯基乙炔基）主链和末端位置的水杨醛部分组成的分子棒与短的10个碱基对DNA序列缀合（以红色显示）。两个这样的共轭物在DNA模板（蓝色）上的组装使两个分子在乙二胺和金属盐的存在下反应，形成金属-salen络合物。
(Figure Presented) A molecular bridge: A molecular rod composed of a substituted oligo (phenylene ethynylene) backbone with salicylaldehyde moieties in the terminal positions was conjugated to short 10-base-pair DNA sequences (shown in red). The assembly of two such conjugates on a DNA template (blue) aligns the two molecules for reaction in the presence of ethylenediamine and a metal salt to form a metal-salen complex.