[The role of nitric oxide in deoxycorticosterone acetate-salt hypertensive rats].
[The role of nitric oxide in deoxycorticosterone acetate-salt hypertensive rats].
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一氧化氮对醋酸去氧皮质酮盐型高血压大鼠的作用[J].
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
K. Kanmatsuse
中科院分区：
文献类型：
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作者：
T. Ishii;Y. Otsuka;T. Okabe;K. Kanmatsuse
本实验观察了醋酸去氧皮质酮盐性高血压大鼠（DOC）血压与一氧化氮（NO）的关系。与对照组相比，术后2周（2 W-DOC）尿NO2- + NO3-（NOx）排泄量（UNOxV）增加，术后4周（4 W-DOC）UNOxV减少。L-精氨酸（Arg-DOC）处理后DOC的BP和UNOxV无明显变化。4 W-DOC和Arg-DOC的主动脉对乙酰胆碱的舒张反应显著降低。4 W-DOC和Arg-DOC去内皮主动脉对脂多糖的舒张反应明显降低。这些数据表明：1）NO合成的短暂增加伴随着血压的升高，但长期血压升高降低了内皮细胞和平滑肌细胞的NO合成：2）补充L-精氨酸对DOC高血压的发生和内皮细胞和平滑肌细胞的NO合成没有影响。
The relationship between nitric oxide (NO) and blood pressure (BP) in deoxycorticosterone acetate-salt hypertensive rats (DOC) was investigated. Although urinary NO2- + NO3- (NOx) excretion (UNOxV) increased 2 weeks after surgery (2W-DOC), UNOxV decreased 4 weeks after surgery (4W-DOC) compared with that of the control. BP and UNOxV did not change in DOC after treatment with L-arginine (Arg-DOC). Aorta from 4W-DOC and Arg-DOC had significantly decreased relaxation responses to acetylcholine. Deendothelialized aorta from 4W-DOC and Arg-DOC had significantly decreased relaxation responses to lipopolysaccharide. These data suggest that: 1) transient increase of NO synthesis is accompanied by elevation of BP, but long-term elevation of BP decreases NO synthesis in endothelium and smooth muscle cells; 2) L-arginine supplement has no effect on the development of hypertension nor on NO production by endothelium and smooth muscle cells in DOC.