Gender-Related Differences in Atherosclerosis
Gender-Related Differences in Atherosclerosis
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DOI：
10.1007/s10557-015-6596-3
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发表时间：
2015-08-01
影响因子：
3.4
通讯作者：
Mehta, Jawahar L.
中科院分区：
文献类型：
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作者：
Mathur, Pankaj;Ostadal, Bohuslav;Mehta, Jawahar L.
动脉粥样硬化性心血管疾病（CVD）是全球发病率和死亡率的主要原因。在过去的几十年里，人们进行了大量的研究来了解动脉粥样硬化的病理生理学。人们普遍认为，雌激素有助于保护绝经前年龄组的女性免受心血管疾病的侵害。然而，临床研究中激素替代疗法未能减少CVD事件，这表明血管生物学与雌激素之间关系的复杂性。有趣的是，女性普遍患有血管和结缔组织疾病，这也表明激素和组织因子在维持血管内皮功能中具有固有的作用。 GPER、脂蛋白 A、TLR、白细胞-血小板聚集标志物在男性和女性中的不同作用也表明动脉粥样硬化病理生理学中固有的性别相关差异。对病理生理学的更好理解可能会为改善女性心血管疾病的循证治疗开辟道路。
Atherosclerotic cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. Considerable research has been done over the last several decades to understand the pathophysiology of atherosclerosis. It is widely believed that estrogen is responsible for the protection of women from CVD in the premenopausal age group. However, hormone replacement therapy has failed to decrease CVD events in clinical studies which points to the complexity of the relationship between vascular biology and estrogen hormones. Interestingly, preponderance of vascular and connective tissue disorders in women also points to an inherent role of hormones and tissue factors in maintenance of vascular endothelial function. The differential effect of GPER, lipoprotein A, TLRs, leucocyte-platelet aggregate markers in men and women also suggests inherent gender-related differences in the pathophysiology of atherosclerosis. A better understanding of the pathophysiology is likely to open ways to improve evidence-based treatment of CVD in women.