Mannich reaction in Bronsted acidic ionic liquid:: A facile synthesis of β-amino carbonyl compounds
Mannich reaction in Bronsted acidic ionic liquid:: A facile synthesis of β-amino carbonyl compounds
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DOI：
10.1016/j.molcata.2005.09.012
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发表时间：
2006-02-01
影响因子：
--
通讯作者：
Halligudi, SB
中科院分区：
文献类型：
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作者：
Sahoo, S;Joseph, T;Halligudi, SB
以1-甲基咪唑和三苯基膦为亲核试剂的Bronsted酸性离子液体与1，4-丁烷磺酸内酯、对甲苯磺酸（PTSA）和三氟乙酸（TFA）为阴离子，催化Mannich反应，以较短的反应时间和较高的产率合成了β-氨基羰基化合物。考察了加入两滴水对产物产率的影响以及离子液体中阴离子和阳离子对反应速率的影响。离子液体很容易通过水萃取从反应混合物中分离出来，并且循环使用四次而没有任何活性损失。(c)2005 Elsevier B. V.保留所有权利。
Bronsted acidic ionic liquid containing nucleophile I-methylimidazole and triphenylphosphine with 1,4-butane sultone and inorganic anions p-toluenesulfonic acid (PTSA) and trifluoroacetic acid (TFA) catalyzed Mannich reaction smoothly to afford beta-amino carbonyl compounds in excellent yield and less time. Effect of addition of two drops of water on the product yield and effect of anions and cations of the ionic liquid on the reaction rate have been investigated. The ionic liquid was easily separated from the reaction mixture by water extraction and was recycled four times without any loss in activity. (c) 2005 Elsevier B.V. All rights reserved.