How the brain repairs stuttering
How the brain repairs stuttering
复制标题
DOI：
10.1093/brain/awp185
复制
发表时间：
2009-10-01
期刊：
影响因子：
14.5
通讯作者：
Giraud, Anne-Lise
中科院分区：
文献类型：
--
作者：
Kell, Christian A.;Neumann, Katrin;Giraud, Anne-Lise
口吃是一种与左下额叶结构异常相关的神经发育障碍。虽然儿童通常会康复，但口吃也可能在多年的流利障碍之后自然消失。这些罕见的成年期独立康复案例提供了在发育可塑性的经典窗口之外进行最佳大脑修复的模型。在这里，我们探讨了这种类型的恢复与不太理想的修复模式的区别，即治疗诱导的辅助恢复和对仍然受到影响的受试者的尝试补偿。我们发现，持续性口吃与结构异常对侧的大脑区域动员以进行补偿尝试有关。相比之下，最佳修复的唯一神经标志是激活眶额皮质中的左侧 BA 47/12，该区域邻近在持续性口吃者中观察到白质异常的区域，但在康复受试者中已正常化。这些发现表明，神经发育性口吃的晚期修复遵循对侧和肛周重组的原则。
Stuttering is a neurodevelopmental disorder associated with left inferior frontal structural anomalies. While children often recover, stuttering may also spontaneously disappear much later after years of dysfluency. These rare cases of unassisted recovery in adulthood provide a model of optimal brain repair outside the classical windows of developmental plasticity. Here we explore what distinguishes this type of recovery from less optimal repair modes, i.e. therapy-induced assisted recovery and attempted compensation in subjects who are still affected. We show that persistent stuttering is associated with mobilization of brain regions contralateral to the structural anomalies for compensation attempt. In contrast, the only neural landmark of optimal repair is activation of the left BA 47/12 in the orbitofrontal cortex, adjacent to a region where a white matter anomaly is observed in persistent stutterers, but normalized in recovered subjects. These findings show that late repair of neurodevelopmental stuttering follows the principles of contralateral and perianomalous reorganization.