Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex
Induced and Evoked Properties of Vibrotactile Adaptation in the Primary Somatosensory Cortex
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DOI：
10.1155/2019/5464096
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发表时间：
2019-01-01
影响因子：
3.1
通讯作者：
McGonigle, David J.
中科院分区：
文献类型：
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作者：
Puts, Nicolaas A. J.;Edden, Richard A. E.;McGonigle, David J.
长时间暴露于传入刺激（适应）会导致皮质感觉神经元反应性的深刻短期变化。虽然已经提出了几种模型，将适应与单神经元动力学联系起来，包括GABA能抑制，但目前在人类全脑水平上对这一过程的理解并不完全。在这里，我们使用脑磁图（MEG）来研究人类SI内适应的神经生理学相关性。在一种条件下，25 Hz适应刺激（5 s）后接1 s 25 Hz探头（相同），在第二种条件下，适应刺激后接1 s 180 Hz探头（不同）。我们假设，μ-β活性带（反映GABA能处理）的变化将在相同和不同的探针刺激之间进行不同的调制。我们发现，初级体感（SI）的μ-β反应相同的探针显着减少（p=0.014）相比，适应刺激，而μ-β反应不同的探针是不是（p=n.s.）。这种减少可能反映了适应后活动的时空模式的尖锐化。25 Hz适应刺激和180 Hz探针之间的刺激起始μ-β反应没有差异，表明μ-β反应与刺激频率无关。此外，我们显示了一个持续的诱发和诱导的desperization适应刺激的持续时间，与侵入性研究一致。我们的研究结果对于理解人类大脑中短期和刺激诱导的可塑性的神经生理学非常重要，并表明大脑对触觉刺激的反应在短暂刺激后会发生改变。
Prolonged exposure to afferent stimulation (adaptation) can cause profound short-term changes in the responsiveness of cortical sensory neurons. While several models have been proposed that link adaptation to single-neuron dynamics, including GABAergic inhibition, the process is currently imperfectly understood at the whole-brain level in humans. Here, we used magnetoencephalography (MEG) to examine the neurophysiological correlates of adaptation within SI in humans. In one condition, a 25Hz adapting stimulus (5s) was followed by a 1s 25Hz probe (same), and in a second condition, the adapting stimulus was followed by a 1s 180Hz probe (different). We hypothesized that changes in the mu-beta activity band (reflecting GABAergic processing) would be modulated differently between the same and different probe stimuli. We show that the primary somatosensory (SI) mu-beta response to the same probe is significantly reduced (p=0.014) compared to the adapting stimulus, whereas the mu-beta response to the different probe is not (p=n.s.). This reduction may reflect sharpening of the spatiotemporal pattern of activity after adaptation. The stimulus onset mu-beta response did not differ between a 25Hz adapting stimulus and a 180Hz probe, suggesting that the mu-beta response is independent of stimulus frequency. Furthermore, we show a sustained evoked and induced desynchronization for the duration of the adapting stimulus, consistent with invasive studies. Our findings are important in understanding the neurophysiology underlying short-term and stimulus-induced plasticity in the human brain and shows that the brain response to tactile stimulation is altered after only brief stimulation.