Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects -: A preliminary study
Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects -: A preliminary study
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DOI：
10.1385/bter:97:3:225
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发表时间：
2004-03-01
影响因子：
3.9
通讯作者：
Çavdar, AO
中科院分区：
文献类型：
--
作者：
Cengiz, B;Söylemez, F;Çavdar, AO
神经管缺陷是婴儿死亡和儿童发病的重要原因。我们调查了锌，硒，铜，铅浓度和神经管缺陷的发生在妇女与中期妊娠终止由于胎儿神经管缺陷（NTDs）在这个病例对照研究。14例因孕中期超声诊断为神经管缺陷而终止妊娠的孕妇被招募为病例。对照组（n = 14）包括从年龄、妊娠和社会经济状况（SES）匹配的妇女中选择的妇女，这些妇女在孕中期进行了正常的三重筛查和靶向超声检查，并记录了正常的胎儿结局。采用火焰原子吸收分光光度计（AAS）测定锌和铜。铅采用石墨炉原子吸收法测定，硒采用氢化物发生原子吸收法测定。例患者血清锌和硒水平显著降低（分别为62.48 ± 15.9 vs 102.6 ± 23.7和55.16 ± 11.3 vs 77.4 ± 5.5，P
Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated as a result of second-trimester ultra-sonographic diagnosis of neural tube defects were recruited as cases. The control group (n = 14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48+/-15.9 vs 102.6+/-23.7 and 55.16+/-11.3 vs 77.4+/-5.5, respectively, p