Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli.
Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli.
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DOI：
10.1016/j.pain.2013.05.030
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发表时间：
2013-09
期刊：
影响因子：
7.4
通讯作者：
Coghill RC
中科院分区：
文献类型：
--
作者：
Lobanov OV;Quevedo AS;Hadsel MS;Kraft RA;Coghill RC
注意力可以深刻地塑造疼痛的体验。然而，人们对支持对伤害性信息进行定向关注的神经机制知之甚少。在本研究中，在与样本辨别任务的延迟匹配期间，提示受试者注意连续呈现的成对的疼痛热刺激的空间位置或强度。我们假设与注意力相关的大脑激活将在注意力提示出现后启动，并在辨别任务中持续存在。联合分析证实，后顶叶皮质的双侧部分（顶内沟、IPS 和顶上小叶）在关注空间而非疼痛强度特征时表现出这种持续的活动。对空间和强度注意力任务期间的激活进行对比分析表明，后顶叶皮层的右侧 IPS 区域在空间任务的多个阶段中始终更加激活。然而，对有害刺激的任一特征的关注都与额顶叶区域（IPS和额叶眼区）的激活以及初级体感皮层的启动有关。总而言之，这些结果描绘了支持选择性放大有害刺激的不同特征以用于判别过程的神经基质。
Attention can profoundly shape the experience of pain. However, little is known about the neural mechanisms that support directed attention to nociceptive information. In the present study, subjects were cued to attend to either the spatial location or intensity of sequentially presented pairs of painful heat stimuli during a delayed match to sample discrimination task. We hypothesized that attention-related brain activation would be initiated following the presentation of the attentional cue and would be sustained through the discrimination task. Conjunction analysis confirmed that bilateral portions of the posterior parietal cortex (intraparietal sulcus, IPS and superior parietal lobule) exhibited this sustained activity during attention to spatial but not intensity features of pain. Analyses contrasting activation during spatial and intensity attention tasks revealed that the right IPS region of the posterior parietal cortex was consistently more activated across multiple phases of the spatial task. However, attention to either feature of the noxious stimulus was associated with activation of fronto-parietal areas (IPS and frontal eye fields) as well as priming of the primary somatosensory cortex. Taken together, these results delineate the neural substrates that support selective amplification of different features of noxious stimuli for utilization in discriminative processes.
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