Ultrasensitive and highly stable nonenzymatic glucose sensor by a CuO/graphene-modified screen-printed carbon electrode integrated with flow-injection analysis
Ultrasensitive and highly stable nonenzymatic glucose sensor by a CuO/graphene-modified screen-printed carbon electrode integrated with flow-injection analysis
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DOI：
10.1016/j.elecom.2013.02.015
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发表时间：
2013-05-01
影响因子：
5.4
通讯作者：
Zen, Jyh-Myng
中科院分区：
文献类型：
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作者：
Sun, Chia-Liang;Cheng, Wan-Ling;Zen, Jyh-Myng
我们在此报道了一种基于氧化铜/石墨烯修饰的丝网印刷碳电极（CuOG - SPCE）并结合流动注射分析（FIA）的非酶葡萄糖传感器。在石墨烯表面上氧化铜纳米粒子分散良好的高活性CuOG - SPCE对葡萄糖具有出色的电催化氧化性能。在最佳的FIA条件下，所提出的生物传感器可用于葡萄糖的定量分析，其线性范围从0.122 μM到0.5 mM，理想灵敏度高达2367 μA mM⁻¹ cm⁻²，同时超低检测限为34.3 nM（信噪比 = 3）。还证明了其具有1.92%（n = 30）的良好重复性，并且抗常见干扰物质（包括抗坏血酸、尿酸、多巴胺、果糖、乳糖和蔗糖）的影响较小。这种对葡萄糖具有高灵敏度、选择性和稳定连续监测（t = 1小时）能力的CuO - SPCE有望用于开发先进的非酶葡萄糖传感器设备。（C）2013爱思唯尔B.V. 版权所有。
We report here a nonenzymatic glucose sensor based on a CuO/graphene-modified screen-printed carbon electrode (CuOG-SPCE) integrated with flow-injection analysis (FIA). The highly active CuOG-SPCE with well-dispersed CuO nanoparticles on graphene surfaces performed excellent electrocatalytic oxidation of glucose. Under optimal FIA conditions, the proposed biosensor can be employed in the quantification of glucose with the linear range from 0.122 mu M to 0.5 mM, the desirable sensitivity up to 2367 mu A mM(-1) cm(-2) and the ultralow detection limit of 34.3 nM (S/N=3) simultaneously. Good repeatability of 1.92% (n=30) and less effects of common interfering species including ascorbic acid, uric acid, dopamine, fructose, lactose and sucrose were also demonstrated. The CuO-SPCE with highly sensitive, selective and stable consecutive monitoring (t=1 h) of glucose is promising for the development of an advanced nonenzymatic glucose sensor device. (C) 2013 Elsevier B.V. All rights reserved.