Catalyst- and solvent-free bisphosphinylation of isothiocyanates: A practical method for the synthesis of bisphosphinoylaminomethanes
Catalyst- and solvent-free bisphosphinylation of isothiocyanates: A practical method for the synthesis of bisphosphinoylaminomethanes
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异硫氰酸酯的无催化剂和无溶剂双膦酰化：合成双膦酰氨基甲烷的实用方法
DOI：
10.1039/c7gc03101g
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Ming Li
中科院分区：
文献类型：
--
作者：
Li-Rong Wen;Yong-Xu Sun;Jin-Wei Zhang;Wei-Si Guo;Ming Li
介绍了一种通用的、简便的异硫氰酸酯双加成氧化膦的方法。这是一种实用的二磷酰氨基甲烷的构造方法。该反应在无金属和无溶剂条件下均能顺利进行。它还具有基材范围广，操作和净化简单的特点。提出了一个可能的机制，涉及串联双亲核加成/H2S消除/原位亚胺还原过程。
A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free conditions. It also features a broad substrate scope, simple operation and purification. A possible mechanism involving a tandem double nucleophilic addition/H2S elimination/in situ imine reduction process is proposed.