Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
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DOI：
10.1126/science.1092089
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发表时间：
2004-02-20
期刊：
影响因子：
56.9
通讯作者：
Hall, A
中科院分区：
文献类型：
--
作者：
Raftopoulou, M;Etienne-Manneville, S;Hall, A
PTEN是一种肿瘤抑制蛋白，可使磷脂酰肌醇3,4,5三磷酸去磷酸化，并拮抗磷脂酰肌醇-3激酶信号通路。我们在这里表明，PTEN也可以通过其C2结构域抑制细胞迁移，独立于其脂质磷酸酶活性。这种活性取决于PTEN蛋白磷酸酶的活性和单个残基苏氨酸的去磷酸化（383）。PTEN通过其C2结构域控制细胞迁移的能力可能是其肿瘤抑制活性的重要特征。
PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine(383). The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.