Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study
Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study
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DOI：
10.1159/000229025
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Anstey, Kaarin J.
中科院分区：
文献类型：
--
作者：
Cherbuin, Nicolas;Reglade-Meslin, Chantal;Anstey, Kaarin J.
目的：本研究旨在确定从正常认知向轻度认知障碍（MCD）转变的身心健康及生活方式预测因素。
方法：共有2082名年龄在60 - 64岁的个体，在相隔4年的两个时间点接受了轻度认知障碍（MCI）及其他轻度认知障碍的评估。
结果：转变为MCI及其他轻度认知障碍的主要预测因素为既往饮酒量、当前使用的抗焦虑和抑郁药物、收缩压升高以及既往吸烟史。
结论：有吸烟或有害饮酒史、高血压，或因焦虑或抑郁而服用药物的参与者转变为MCI或任何轻度认知障碍的风险增加。针对管理上述风险因素的策略可能有益于预防社区中相对健康的中年个体出现轻度认知衰退。
版权所有（c）2009 S. Karger AG，巴塞尔
Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community. Copyright (c) 2009 S. Karger AG, Basel