Effects of short-term JP-8 jet fuel exposure on cell-mediated immunity
Effects of short-term JP-8 jet fuel exposure on cell-mediated immunity
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DOI：
10.1191/074823300678827681
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发表时间：
2000-02-01
影响因子：
1.9
通讯作者：
Witten, M
中科院分区：
文献类型：
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作者：
Harris, DT;Sakiestewa, D;Witten, M
美国空军已经在其行动中广泛使用JP-8喷气燃料，尽管其对暴露人员的潜在影响尚不清楚。暴露于环境毒物如JP-8可能对宿主生理产生显著影响。航空燃油暴露已被证明会导致人类肝功能障碍，异常脑电图，注意力持续时间缩短，感觉运动速度下降。先前的研究表明，短期、低浓度的JP-g暴露对免疫系统有显著影响;例如，存活免疫细胞数目减少、免疫器官重量减少和免疫功能丧失持续延长的时间（即，暴露后4周）。在本研究中，对JP-8暴露对细胞免疫的影响进行了深入分析。在小鼠中进行短期（7天，1小时/天）低浓度（1000 mg/m3）暴露，并在最后一次暴露后24小时分析T细胞和自然杀伤（NK）细胞功能。暴露方案被发现几乎完全消融NK细胞功能，以及显着抑制淋巴因子激活的杀伤（LAK）细胞活性的产生。此外，JP-8暴露抑制前体T细胞产生细胞毒性T淋巴细胞（CTL）细胞，并抑制辅助性T细胞活性。这些发现表明，JP-8喷气燃料暴露对暴露个体的免疫功能具有显著的不利影响。JP-8喷气燃料应被认为是一种潜在的和重要的免疫毒物。长期暴露于JP-8可能对暴露个体的长期健康产生严重影响。
The U.S. Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Exposure to environmental toxicants such as JP-8 may have significant effects on host physiology. Jet fuel exposure has been shown to cause human liver dysfunction, abnormal electroencephalograms, shortened attention spans, and decreased sensorimotor speed. Previous studies have shown that short-term, low-concentration JP-g exposure had significant effects on the immune system; e.g., decreased viable immune cell numbers, decreased immune organ weights, and loss of immune function that persisted for extended periods of time (i.e., up to 4 weeks post-exposure). In the current study, an in-depth analysis of the effects of JP-8 exposure on cellular immunity was performed. Short-term (7 days, 1 h/day), low-concentration (1000 mg/m(3)) exposures were conducted in mice, and T cell and natural killer (NK) cell functions were analyzed 24 h alter the last exposure. The exposure regimen was found to almost completely ablate NK cell function, as well as significantly suppress the generation of lymphokine-activated killer (LAK) cell activity. Furthermore, JP-8 exposure suppressed the generation of cytotoxic T lymphocyte (CTL) cells from precursor T cells, and inhibited helper T cell activity. These findings demonstrate that JP-8 jet fuel exposure has significant detrimental effects on immune functions of exposed individuals. JP-8 jet fuel should be considered a potential and significant immunotoxicant. Chronic exposure to JP-8 may have serious implications to the long-term health of exposed individuals.