The Effects of Intranasal Oxytocin Administration on Sensitive Caregiving in Mothers with Postnatal Depression.
The Effects of Intranasal Oxytocin Administration on Sensitive Caregiving in Mothers with Postnatal Depression.
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DOI：
10.1007/s10578-016-0642-7
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发表时间：
2017-04
影响因子：
2.9
通讯作者：
Bakermans-Kranenburg MJ
中科院分区：
文献类型：
--
作者：
Mah BL;Van Ijzendoorn MH;Out D;Smith R;Bakermans-Kranenburg MJ
产后抑郁症（PND）是常见的，并对母婴关系产生负面影响;催产素（OT）已被发现对育儿有积极影响，尽管精神疾病可能会减少这些影响。因此，我们探讨了OT在诊断为PND的母亲中的作用。采用受试者内随机对照双盲设计，检测鼻内给予OT或安慰剂对敏感性降低的影响。结果的措施是感知和预录的哭声的反应，以及观察到的母亲的敏感性。我们发现，在OT条件下，患有PND的母亲更有可能将婴儿的哭声视为更紧急，并且更有可能表示他们会选择严厉的回应策略。OT对母亲与自己婴儿的敏感互动没有影响。需要进一步的研究之前，考虑OT管理抑郁症的母亲的婴儿。
Postnatal depression (PND) is common and negatively affects the mother–infant relationship; oxytocin (OT) has been found to have positive effects on parenting, although psychiatric disorders may reduce these effects. Thus, we explored the role of OT in mothers diagnosed with PND. A within-subject, randomized controlled double-blind design was used to test the effects of nasal administration of OT or placebo on sensitive caregiving. The outcome measures were perceptual and caregiving responses to prerecorded cry sounds, as well as observed maternal sensitivity. We found that in the OT condition mothers with PND were more likely to rate an infant cry as more urgent and they were more likely to indicate they would chose a harsh caregiving strategy in response. There was no effect of OT on maternal sensitive interaction with their own baby. Further research is required prior to consideration of OT administration in depressed mothers of infants.