Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients
Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients
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DOI：
10.1002/gcc.22479
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发表时间：
2018-01-01
影响因子：
3.7
通讯作者：
Arai, Tomio
中科院分区：
文献类型：
--
作者：
Matsuda, Yoko;Tanaka, Masashi;Arai, Tomio
我们根据胰腺病变、临床信息和单核苷酸多态性（snp）对连续尸检的日本老年胰腺上皮内瘤样增生（PanINs）和胰腺导管腺癌（PDACs）患者（n = 2205）进行比较分析。这些患者中PanIN-1、-2、-3和pdac的发生率分别为55%、12%、1.4%和2.4%。PanINs的发生与女性、年龄增长和较低的身体质量指数有关。我们没有发现PanINs和pdac之间有任何共同的snp。在男性和女性之间没有与PanINs和pdac相关的共同snp。在先前报道的胰腺癌相关snp中，rs3790844 （NR5A2）在我们的队列中显示与PDAC显著相关。与血脂水平相关的6个snp （rs7016880、rs10096633、rs10503669、rs12678919、rs17482753、rs328）与患pdac的风险相关。我们的数据表明，不同的临床病理特征和易感性可能影响日本老年患者的胰腺癌发生。
We comparatively analyzed serially autopsied, elderly Japanese patients (n = 2205) with pancreatic intraepithelial neoplasias (PanINs) and pancreatic ductal adenocarcinomas (PDACs) on the basis of their pancreatic lesions, clinical information, and single nucleotide polymorphisms (SNPs). The incidence of PanIN-1, -2, -3, and PDACs in these patients was 55%, 12%, 1.4%, and 2.4%, respectively. The occurrence of PanINs was associated with female sex, increasing age, and lower body mass index. We did not identify any common SNPs between PanINs and PDACs. There were no common SNPs associated with PanINs and PDACs between men and women. In previously reported pancreatic cancer-associated SNPs, rs3790844 (NR5A2) showed a significant correlation with PDAC in our cohort. Six SNPs (rs7016880, rs10096633, rs10503669, rs12678919, rs17482753, rs328) that were correlated with blood lipid levels were associated with the risk for PDACs. Our data suggest that different clinicopathological characteristics and predispositions may affect pancreatic carcinogenesis in elderly Japanese patients.