THE ASSOCIATION OF KNEE INJURY AND OBESITY WITH UNILATERAL AND BILATERAL OSTEO-ARTHRITIS OF THE KNEE
THE ASSOCIATION OF KNEE INJURY AND OBESITY WITH UNILATERAL AND BILATERAL OSTEO-ARTHRITIS OF THE KNEE
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DOI：
10.1093/oxfordjournals.aje.a115334
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发表时间：
1989-08-01
影响因子：
5
通讯作者：
HAUCK, WW
中科院分区：
文献类型：
--
作者：
DAVIS, MA;ETTINGER, WH;HAUCK, WW
在1971-1975年的第一次全国健康和营养检查调查中，对3,885名45-74岁接受膝关节X光检查的成年人进行了膝关节损伤和肥胖与膝关节骨关节炎之间联系的强度研究。双侧骨关节炎的患病率（5%）高于单侧骨关节炎（2%）。女性双侧骨关节炎的患病率是男性的两倍;然而，单侧骨关节炎的患病率没有性别差异。通过多分类逻辑回归计算的比值比表明，肥胖、膝关节损伤和年龄与单侧和双侧膝关节骨关节炎显著相关。与膝关节损伤相比，肥胖是双侧骨关节炎更强的预测因子（肥胖的比值比（OR）= 6.6，右膝损伤为3.5，左膝损伤为3.0; 95%置信区间（CI）分别为4.71-9.18、1.80-6.83和1.51-6.11）。与肥胖相比，膝关节损伤是单侧骨关节炎更强的预测因子（右膝和左膝肥胖的OR分别为3.4和2.4（95% CI 1.55-7.29和0.96-5.75），右膝和左膝损伤的OR分别为16.3和10.9，95% CI分别为6.50-40.89和3.72-31.93）。这些结果表明，单侧和双侧膝关节骨关节炎可能存在不同的发病过程。
The strength of the associations of knee injury and obesity with osteoarthritis of the knee was studied for 3,885 adults aged 45-74 years who received knee x-rays in the First National Health and Nutrition Examination Survey, 1971-1975. Bilateral osteoarthritis was more prevalent (5%) than unilateral osteoarthritis (2%). Bilateral osteoarthritis was twice as prevalent in women as in men; however, there was no sex difference in the prevalence of unilateral osteoarthritis. Odds ratios calculated by means of polychotomous logistic regression indicated that obesity, knee injury, and age were significantly associated with both unilateral and bilateral knee osteoarthritis. Obesity was a stronger predictor of bilateral osteoarthritis than was knee injury (odds ratio (OR) = 6.6 for obesity, 3.5 for right knee injury, and 3.0 for left knee injury; 95% confidence interval (CI) 4.71-9.18, 1.80-6.83, and 1.51-6.11, respectively). Knee injury was a stronger predictor of unilateral osteoarthritis than was obesity (OR = 3.4 and 2.4 for obesity in the right and left knee, respectively (95% CI 1.55-7.29 and 0.96-5.75) and OR = 16.3 and 10.9 for injury in the right and left knee, respectively (95% CI 6.50-40.89 and 3.72-31.93)). These findings suggest that different pathogenetic processes may exist for unilateral and bilateral knee osteoarthritis.