Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study
Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study
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DOI：
10.1136/annrheumdis-2015-208360
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发表时间：
2016-10-01
影响因子：
27.4
通讯作者：
Ding, Changhai
中科院分区：
文献类型：
--
作者：
Han, Weiyu;Aitken, Dawn;Ding, Changhai
目的 描述基线时髌下脂肪垫 (IPFP) 信号强度变化与老年人膝关节症状和结构变化之间的关联。 方法 从当地社区随机抽取 874 名受试者（平均 62.1 岁，50.1% 女性）进行基线研究，并对 770 名受试者进行了超过 2.6 年的随访（仅 357 名受试者在随访时进行了 MRI）。 T1 加权或 T2 加权脂肪抑制 MRI 用于评估基线和 2.6 年后的 IPFP 信号强度变化 (0-3)、软骨体积、软骨缺陷和骨髓病变 (BML)。通过自我管理的西安大略和麦克马斯特骨关节炎指数问卷评估膝关节疼痛。评估放射学骨关节炎 (OA)。 结果 在横断面分析中，IPFP 信号强度变化与全膝关节疼痛以及膝关节软骨缺损、BML 和膝关节放射学 OA 呈显着正相关，在调整年龄、性别、体重指数和/或放射学 OA 后与髌骨软骨体积呈负相关。纵向上，IPFP 内基线信号强度的变化与上楼/下楼时膝关节疼痛的增加以及胫股软骨缺损和 BML 的增加呈显着正相关，并且与多变量分析中胫骨外侧软骨体积的变化呈负相关。膝骨关节炎。
Objective To describe the associations between infrapatellar fat pad (IPFP) signal intensity alteration at baseline and knee symptoms and structural changes in older adults.Methods A total of 874 subjects (mean 62.1years, 50.1% female) selected randomly from local community were studied at baseline and 770 were followed up (only 357 had MRI at follow-up) over 2.6years. T1-weighted or T2-weighted fat suppressed MRI was used to assess IPFP signal intensity alteration (0-3), cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and 2.6years later. Knee pain was assessed by self-administered Western Ontario and McMaster Osteoarthritis Index questionnaire. Radiographic osteoarthritis (OA) was assessed.Results In cross-sectional analyses, IPFP signal intensity alteration was significantly and positively associated with total knee pain as well as knee cartilage defects, BMLs and knee radiographic OA and negatively associated with patellar cartilage volume after adjustment for age, sex, body mass index and/or radiographic OA. Longitudinally, baseline signal intensity alteration within IPFP was significantly and positively associated with increases in knee pain when going upstairs/downstairs as well as increases in tibiofemoral cartilage defects and BMLs, and negatively associated with change in lateral tibial cartilage volume in multivariable analyses.Conclusions IPFP signal intensity alteration at baseline was associated with knee structural abnormalities and clinical symptoms cross-sectionally and longitudinally in older adults, suggesting that it may serve as an important imaging biomarker in knee OA.