FOS AND JUN IN RAT CENTRAL AMYGDALOID NUCLEUS AND PARAVENTRICULAR NUCLEUS AFTER STRESS
FOS AND JUN IN RAT CENTRAL AMYGDALOID NUCLEUS AND PARAVENTRICULAR NUCLEUS AFTER STRESS
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DOI：
10.1097/00001756-199210000-00007
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发表时间：
1992-10-01
期刊：
影响因子：
1.7
通讯作者：
PELTOHUIKKO, M
中科院分区：
文献类型：
--
作者：
HONKANIEMI, J;KAINU, T;PELTOHUIKKO, M
本文应用原位杂交技术研究了辣椒素诱导的应激刺激对下丘脑室旁核（PVN）和中央杏仁核（ACe）内即早基因（IEGs）c-fos、c-jun、junB和junD表达的影响。应激引起c-fos、c-jun和junB的强烈表达，尤其是在PVN和ACe中，并且在PVN中观察到明显的junD诱导。这表明PVN和ACe是大脑中压力的两个主要目标。在ACe和PVN的IEGs的强烈表达表明，压力可能会影响神经递质基因的表达，通过Fos和Jun蛋白在这两个核。
THE present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization. Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN. This suggests that the PVN and the ACe are two major targets of stress in the brain. The intense expression of the IEGs in the ACe and PVN suggests that stress may affect neurotransmitter gene expression through Fos and Jun proteins in both these nuclei.