Factors controlling renin in man.
Factors controlling renin in man.
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控制人体内肾素的因素。
DOI：
10.1001/archinte.1966.03870090039007
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发表时间：
1966
期刊：
影响因子：
--
通讯作者：
R. Boucher
中科院分区：
文献类型：
--
作者：
J. Champlain;J. Genest;Robert Veyratt;R. Boucher
肾素-血管紧张素系统相关的领域在过去几年中得到了很大的推动，因为越来越多的证据表明血管紧张素对醛固酮分泌有直接和特异性的影响，也因为有了更具体、准确、敏感和可重复的方法来测量动脉血管紧张素水平和外周血肾素活性水平。我们实验室最近的工作有力地表明，肾素-血管紧张素系统，钠调节，某些高血压实体和大多数以醛固酮分泌显著变化为特征的疾病之间存在着非常密切的关系。因此，研究控制人体肾素的可能因素具有重要意义。在本报告中，我们希望描述我们关于三个可能因素的研究：(1)钠摄入或排泄，(2)血管紧张素，(3)长时间和过量的醛固酮分泌。方法和对象本程序用于测量外周
THE FIELD related to the renin-angiotensin system has received great impetus in the last few years because of the accumulating evidence which demonstrates the direct and specific effect of angiotensin on aldosterone secretion and because of the availability of more specific, accurate, sensitive and reproducible methods for measurement of arterial angiotensin levels and of peripheral blood renin activity levels. Recent work from our laboratory strongly suggests that there is a very close relationship between, on one hand, the renin-angiotensin system, and, on the other hand, sodium regulation, some hypertensive entities, and most conditions characterized by significant changes in aldosterone secretion.1-7Studies concerning possible factors controlling renin in man assume therefore great importance. In this presentation, we wish to describe our studies concerning three possible factors: (1) sodium intake or excretion, (2) angiotensin, and (3) prolonged and excessive aldosterone secretion. Methods and Subjects The procedure used for measurement of peripheral