REACTIVE HYPEREMIA CHARACTERISTICS OF THE MYOCARDIUM
REACTIVE HYPEREMIA CHARACTERISTICS OF THE MYOCARDIUM
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DOI：
10.1152/ajplegacy.1960.199.6.1143
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发表时间：
1960-01-01
影响因子：
--
通讯作者：
GREGG, DE
中科院分区：
文献类型：
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作者：
COFFMAN, JD;GREGG, DE
本文用连续记录的血流计研究了麻醉开胸犬冠状动脉左回旋支结扎前后的血流变化。进行5 - 180秒的闭塞期。超过控制流量（反应性充血）的流量、峰值流量和反应性充血持续时间在c闭塞后增加约2分钟。流量债务估计控制流量闭塞前几乎总是多付。一系列30秒的闭塞表明，反应性充血血流反应在同一只狗中是均匀的。在15只犬中，药物对心肌反应性充血的影响是可变的;异丙肾上腺素、左肾上腺素和肾上腺素通常不改变或增加，而Pitressin减少反应性充血血流量。结论：心肌缺氧反应是一个可重复的现象，随缺氧时间延长而增强，受药物影响较小，心肌缺氧的流量债过高。
Blood flow before and after occlusion of cannulated left circumflex coronary arteries of anesthetized open-chest dogs was studied using a continuously recording rotameter. Five- to one hundred and eighty-seconds occlusion periods were performed. Flow in excess of control flow (reactive hyperemia), peak flow, and duration of reactive hyperemia increased in magnitude following c occlusions up to approximately 2 minutes. Flow debts estimated from control flows before occlusion were almost always overpaid. Series of 30-seconds occlusions showed that the reactive hyperemic blood flow responses were uniform in the same dog. In 15 dogs, the effect of drugs on myocardial reactive hyperemia was variable; isoproterenol, levarterenol and epinephrine usually did not alter or increased, while Pitressin decreased, reactive hyperemic blood flow. It is concluded that the myocardial response to anoxia is a reproducible phenomenen, increases with lengthening period of anoxia, is variably affected by drugs and that the estimated flow debt for myocardial anoxia is overpaid.