Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum
Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum
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DOI：
10.1016/j.schres.2006.01.016
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发表时间：
2006-04
影响因子：
4.5
通讯作者：
Tsutomu Takahashi;Michio Suzuki;Shi-Yu Zhou;R. Tanino;H. Hagino;Y. Kawasaki;M. Matsui;H. Seto;M. Kurachi
中科院分区：
文献类型：
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作者：
Tsutomu Takahashi;Michio Suzuki;Shi-Yu Zhou;R. Tanino;H. Hagino;Y. Kawasaki;M. Matsui;H. Seto;M. Kurachi
精神分裂症患者的上级颞回（STG）及其亚区域如Heschl's回（HG）或颞平面（PT）的形态学异常已有报道，但尚未在精神分裂症患者中进行广泛研究。在本研究中，磁共振图像采集65例精神分裂症患者，39例典型障碍患者，和72名健康对照。使用颞极（TP）和上级颞分区[极平面（PP）、HG、PT、吻侧STG和尾侧STG]的连续1 mm冠状切片进行容积分析。精神分裂症患者的HG明显小于对照组，但在非典型患者中则不然，而左侧PT和双侧尾侧STG的体积减少在两种疾病中是常见的。与女性精神分裂症患者相比，女性精神分裂症患者的TP灰质更大。PP和吻侧STG体积无显著组间差异。在早期精神分裂症患者亚组（病程<1.0年）中，左侧PP和吻侧STG体积较小与幻觉和妄想相关。我们的研究结果表明，STG后部区域的形态学变化是常见的精神分裂症谱，而较少涉及的HG，可能PP和吻侧STG可能与保留从发展明显的精神病的典型患者。
Morphologic abnormalities of the superior temporal gyrus (STG) as well as its sub-regions such as Heschl's gyrus (HG) or planum temporale (PT) have been reported in schizophrenia patients, but have not been extensively studied in schizotypal subjects. In the present study, magnetic resonance images were acquired from 65 schizophrenia patients, 39 schizotypal disorder patients, and 72 healthy controls. Volumetric analyses were performed using consecutive 1-mm coronal slices on the temporal pole (TP) and superior temporal sub-regions [planum polare (PP), HG, PT, rostral STG, and caudal STG]. The HG was significantly smaller in schizophrenia patients compared with controls but not in schizotypal patients, while volume reductions of the left PT and bilateral caudal STG were common to both disorders. The TP gray matter was larger in female schizotypal patients compared with female schizophrenia patients. There were no significant group differences in the PP and rostral STG volume. In the subgroup of early phase schizophrenia patients (illness duration <1.0 year), smaller volumes for the left PP and rostral STG were correlated with hallucinations and delusions. Our findings suggest that morphologic changes in the posterior regions of the STG are common to the schizophrenia spectrum, whereas less involvement of the HG, and possibly the PP and rostral STG might be related to the sparing of schizotypal patients from developing overt psychosis.