Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population.
Three single nucleotide polymorphisms associated with type 2 diabetes mellitus in a Chinese population.
复制标题
与中国人群2型糖尿病相关的三种单核苷酸多态性
DOI：
10.3892/etm.2016.3920
复制
发表时间：
2017-01
影响因子：
2.7
通讯作者：
Qiao H
中科院分区：
文献类型：
--
作者：
Chen M;Zhang X;Fang Q;Wang T;Li T;Qiao H
印度的一项研究最近观察到三个新的基因座：SGCG中的rs 9552911，PLXNA 4附近的rs 1593304和SCAP中的rs4858889与南亚人群中的2型糖尿病（T2 DM）相关。本研究的目的是在中国人群中验证这些发现。我们在一组1,972名中国人中对上述三种单核苷酸多态性（SNPs）rs 9552911、rs 1593304和rs4858889进行了基因分型，其中包括966名2型糖尿病患者和976名对照。测量所有参与者的人体测量变量和生化特征。估计了基因型-病害和基因型-性状的关联分析。rs 9552911基因型频率在病例组和对照组之间差异有统计学意义（P=0.017）。在非肥胖参与者中，病例组和对照组之间的差异也很明显（P=0.033）。此外，SNP rs 9552911与体重（P=0.033）、总胆固醇（P=0.006）和低密度脂蛋白胆固醇（P=0.007）相关。SNP rs 1593304与通过β细胞功能的稳态模型评估估计的β细胞功能相关（P=0.041）。然而，rs4858889与T2 DM之间没有显著关联。总之，结果表明SNP rs 9552911与T2 DM相关，可能通过影响体重指数和脂质代谢。SNP rs 1593304可能损害β细胞功能。
An Indian study recently observed three new loci: rs9552911 in the SGCG, rs1593304 near PLXNA4 and rs4858889 in SCAP associated with type 2 diabetes mellitus (T2DM) in a south Asian population. The present study aimed to validate these findings in a Chinese population. We genotyped the above three single-nucleotide polymorphisms (SNPs), rs9552911, rs1593304, and rs4858889, in a group of 1,972 Chinese individuals, comprising of 966 type 2 diabetic patients and 976 controls. Anthropometric variables and biochemical traits were measured in all the participants. The association analyses of genotype-disease and genotype-traits were estimated. The genotype frequency of rs9552911 differed statistically between the cases and controls (P=0.017). The difference was also evident between the cases and controls in non-obese participants (P=0.033). In addition, the SNP rs9552911 was associated with weight (P=0.033), total cholesterol (P=0.006) and low-density lipoprotein-cholesterol (P=0.007). The SNP rs1593304 was associated with β-cell function estimated by the homeostatic model assessment of β-cell function (P=0.041). However, there was no significant association between rs4858889 and T2DM. In conclusion, the results show that the SNP rs9552911 was associated with T2DM, possibly by affecting body mass index and lipid metabolism. The SNP rs1593304 may impair β-cell function.