Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
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DOI：
10.1016/j.tibs.2015.08.006
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发表时间：
2015-11
影响因子：
13.8
通讯作者：
Symington LS
中科院分区：
文献类型：
--
作者：
Sfeir A;Symington LS
DNA双链断裂（DSB）破坏了染色体的连续性，通过无错误的机制进行修复对于保持基因组的完整性至关重要。微同源介导的末端连接（MMEJ）是一种易错修复机制，其涉及连接前断裂末端内部的微同源序列的比对，并且与标记原始断裂位点的缺失和插入以及染色体易位相关。MMEJ是否具有生理作用或仅仅是一种备用修复机制是一个有争议的问题。在这里，我们回顾了最近的研究结果有关的机制MMEJ和讨论其在正常和癌细胞中的作用。
DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by error-free mechanisms is essential to preserve genome integrity. Microhomology-mediated end joining (MMEJ) is an error-prone repair mechanism that involves alignment of microhomologous sequences internal to the broken ends before joining, and is associated with deletions and insertions that mark the original break site, as well as chromosome translocations. Whether MMEJ has a physiological role or is simply a back-up repair mechanism is a matter of debate. Here we review recent findings pertaining to the mechanism of MMEJ and discuss its role in normal and cancer cells.