Health-related Quality of Life in Patients with Idiopathic Pulmonary Fibrosis - Cross-sectional and Longitudinal Study
Health-related Quality of Life in Patients with Idiopathic Pulmonary Fibrosis - Cross-sectional and Longitudinal Study
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DOI：
10.2169/internalmedicine.46.6218
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发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Iwasaki, Hironobu
中科院分区：
文献类型：
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作者：
Tomioka, Hiromi;Imanaka, Kazufumi;Iwasaki, Hironobu
目的 验证医疗结果研究简表 36 (SF-36) 在测量特发性肺纤维化 (IPF) 患者健康相关生活质量 (HRQL) 方面的横断面和纵向使用。方法 患者接受 SF-36 治疗，同时接受实验室和生理测试以及高分辨率计算机断层扫描 (HRCT)。 46 名患者参与了最初的横断面研究，32 名患者在一年多后在相同条件下再次接受了这些研究。 结果 与一般人群相比，IPF 患者在 SF-36 的所有 8 个领域的得分均显着较低。在 2 个物理领域观察到 HRQL 显着下降。根据生理参数的恶化，一些领域的受试者内部变化存在显着差异。肺活量占预测值的百分比与 6 个分量表的结果显着相关，其变化与 4 个分量表的结果显着相关。 6分钟步行距离与3个分量表显着相关，其变化与4个分量表显着相关。 HRCT毛玻璃评分的变化与3个分量表的变化显着相关。 3个领域的变化与任何临床参数的变化均未观察到显着相关性。结论IPF患者的HRQL在生理和心理功能上均显着受损。随着时间的推移，这种疾病明显降低了 HRQL 的身体方面。 HRQL 仪器应纳入 IPF 患者的常规评估中，因为它们测量的尺寸并未通过临床评估完全估计。
Object To validate the cross-sectional and longitudinal use of the Medical Outcome Study Short Form 36 (SF-36) for measuring health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF).Methods Patients were administered the SF-36 and concomitantly underwent laboratory and physiologic tests and high-resolution computed tomography (HRCT). Forty-six patients participated in the initial cross-sectional study, and 32 patients who were available more than one year later again underwent these studies under the same conditions.Results Patients with IPF had significantly lower scores across all 8 domains of the SF-36 when compared with the general population. Significant decline of HRQL was observed in 2 physical domains. There were significant differences in within-subject changes in a few domains according to worsening of the physiologic parameters. Vital capacity as percent of predicted was significantly correlated with the results of 6 subscales and its changes were significantly correlated with those of 4 subscales. The 6-min-walk distance was correlated significantly with 3 subscales and its changes were significantly correlated with those of 4 subscales. Changes in the HRCT ground-glass score were significantly correlated with those of 3 subscales. No significant correlations between changes in 3 domains and those of any clinical parameters were observed.Conclusion Patients with IPF had significantly impaired HRQL in both physical and psychological functions. This disease clearly decreased the physical aspects of HRQL over time. HRQL instruments should be incorporated into routine evaluations of IPF patients, since they measure dimensions not fully estimated by clinical assessment.