Sleep-disordered breathing in stable methadone programme patients: a pilot study.
Sleep-disordered breathing in stable methadone programme patients: a pilot study.
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DOI：
10.1046/j.1360-0443.2001.9633954.x
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发表时间：
2001-03
期刊：
影响因子：
6
通讯作者：
H. Teichtahl;Andy Prodromidis;B. Miller;G. Cherry;I. Kronborg
中科院分区：
文献类型：
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作者：
H. Teichtahl;Andy Prodromidis;B. Miller;G. Cherry;I. Kronborg
目的探讨稳定期MMP患者存在睡眠呼吸障碍（SDB）和夜间睡眠阶段及睡眠效率异常睡眠结构的可能性。设计的观测。某大学附属医院美沙酮服务及睡眠障碍区域实验室。参与者和测量。10例稳定型MMP患者和9例正常受试者进行临床和夜间多导睡眠图评估。结果：两组患者的年龄、性别和体重指数均无差异。美沙酮的剂量在50到120毫克/天之间。6例患者中枢呼吸暂停指数（CAI）大于5,4例患者CAI大于10，其中3例患者出现周期性呼吸。没有正常受试者出现中枢性睡眠呼吸暂停。患者睡眠效率低于对照组（p < 0.05），慢波睡眠少于对照组（p < 0.01），快速眼动睡眠少于对照组（p < 0.05），第二阶段睡眠多于对照组（p < 0.05）。结论：稳定型MMP患者比对照组有更多的睡眠结构异常和更高的中枢性睡眠呼吸暂停患病率。需要进一步的研究来证实这些发现，描述异常的机制，并评估SDB是否与稳定的MMP患者的猝死有关。我们建议对MMP患者进行清醒和睡眠呼吸评估，以确定潜在的风险。
AIMS To explore the possibility that stable MMP patients have sleep-disordered breathing (SDB) and abnormal sleep architecture defined by nocturnal sleep stages and sleep efficiency. DESIGN Observational. SETTING Regional Methadone Service and sleep disorders laboratory in a university affiliated hospital. Participants and measurements. Ten stable MMP patients and nine normal subjects were assessed clinically and with overnight polysomnography. FINDINGS There were no differences in age, sex and body mass index between the groups. The methadone dose ranged between 50 and 120 mg/day. Six patients had central apnoea index (CAI) greater than 5, four had a CAI greater than 10 and three of these exhibited periodic breathing. No normal subject had central sleep apnoea. The patients had lower sleep efficiency (p < 0.05), less slow wave sleep (p < 0.01), less rapid eye movement sleep (p < 0.05) and more Stage 2 sleep (p < 0.05) than controls. CONCLUSIONS Stable MMP patients have more sleep architecture abnormalities than controls and a higher prevalence of central sleep apnoea. Further studies are needed to confirm these findings, to delineate the mechanisms for the abnormalities and to assess whether the SDB is related to sudden death in stable MMP patients. We recommend that MMP patients have awake and sleep respiration assessed to identify those potentially at risk.