Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force
Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: Report of the Indian Society of Gastroenterology Task Force
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DOI：
10.1007/s12664-011-0112-x
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发表时间：
2011-05-01
影响因子：
2
通讯作者：
Srinivasan, R.
中科院分区：
文献类型：
--
作者：
Bhatia, Shobna;Reddy, D.;Srinivasan, R.
背景胃食管反流病（GERD）及其并发症在印度并不常见;印度没有关于GERD患病率和危险因素的数据。印度胃肠病学会成立了一个工作组，旨在研究：（a）在印度的频率和GERD的概况，（B）因素，包括饮食与GERD.Methods在这个前瞻性的，多中心（12个中心）的研究，数据使用问卷从3224名受试者获得有关的频率，严重程度和持续时间的胃灼热，反流和其他症状的GERD。还获得了关于他们的饮食习惯，成瘾和生活方式的数据，以及这些数据是否与症状有关或因症状而改变。结果3224例患者中有245例（7.6%）每周至少有一次胃灼热和/或反流。在单变量分析中，年龄较大（OR 1.012; 95% CI 1.003-1.021）、非素食和油炸食品、充气饮料、茶/咖啡的消费与GERD相关。吸烟频率在有或无GERD的受试者中相似。有和无GERD的受试者的体重指数（BMI）相似。在多变量分析中，非素食食物的消费与GERD症状独立相关。与肠易激综合征症状重叠并不罕见; 21%的患者报告排便困难，9%的患者粪便中有粘液。约25%的患者曾咨询过医生以前为他们的胃肠道symptoms.Conclusion 7.6%的印度受试者有显着的GERD症状。非素食食物的消费是GERD的独立预测因子。有或无GERD的受试者的BMI相当。
Background Gastroesophageal reflux disease (GERD) and its complications are thought to be infrequent in India; there are no data from India on the prevalence of and risk factors for GERD. The Indian Society of Gastroenterology formed a task force aiming to study: (a) the frequency and profile of GERD in India, (b) factors including diet associated with GERD.Methods In this prospective, multi-center (12 centers) study, data were obtained using a questionnaire from 3224 subjects regarding the frequency, severity and duration of heartburn, regurgitation and other symptoms of GERD. Data were also obtained regarding their dietary habits, addictions, and lifestyle, and whether any of these were related or had been altered because of symptoms. Data were analyzed using univariate and multivariate methods.Results Two hundred and forty-five (7.6%) of 3224 subjects had heartburn and/or regurgitation at least once a week. On univariate analysis, older age (OR 1.012; 95% CI 1.003-1.021), consumption of non-vegetarian and fried foods, aerated drinks, tea/coffee were associated with GERD. Frequency of smoking was similar among subjects with or without GERD. Body mass index (BMI) was similar in subjects with and without GERD. On multivariate analysis, consumption of non-vegetarian food was independently associated with GERD symptoms. Overlap with symptoms of irritable bowel syndrome was not uncommon; 21% reported difficulty in passage of stool and 9% had mucus in stools. About 25% of patients had consulted a doctor previously for their gastrointestinal symptoms.Conclusion 7.6% of Indian subjects have significant GERD symptoms. Consumption of non-vegetarian foods was an independent predictor of GERD. BMI was comparable among subjects with or without GERD.